Matrices, scaffolds & carriers for cell delivery in nerve regeneration.

Matrices, scaffolds & carriers for cell delivery in nerve regeneration.
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DOI:
10.1016/j.expneurol.2018.09.020
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发表时间:
2019-09
影响因子:
5.3
通讯作者:
Sakiyama-Elbert SE
Sakiyama-Elbert SE
中科院分区:
医学2区
文献类型:
--
作者:
Wang ZZ;Sakiyama-Elbert SE

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神经损伤可能是终身衰弱的创伤,严重影响患者的生活质量。虽然已经开发了许多脱细胞神经支架来帮助神经再生过程,但完全的功能恢复仍然很难实现,特别是对于长间隙周围神经损伤和大多数脊髓损伤病例。基于细胞的疗法已经显示出许多改善神经再生的有希望的结果。随着神经组织工程的发展,生物材料支架与细胞移植相结合的方法有望成为促进神经再生的新途径。本文综述了设计细胞载体生物材料支架的重要考虑因素。它还讨论了目前用于支架的生物材料,为改善细胞移植提供了许可和指导性的微环境。
Nerve injuries can be life-long debilitating traumas that severely impact patients’ quality of life. While many acellular neural scaffolds have been developed to aid the process of nerve regeneration, complete functional recovery is still very difficult to achieve, especially for long-gap peripheral nerve injury and most cases of spinal cord injury. Cell-based therapies have shown many promising results for improving nerve regeneration. With recent advances in neural tissue engineering, the integration of biomaterial scaffolds and cell transplantation are emerging as a more promising approach to enhance nerve regeneration. This review provides an overview of important considerations for designing cell-carrier biomaterial scaffolds. It also discusses current biomaterials used for scaffolds that provide permissive and instructive microenvironments for improved cell transplantation.
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