Matrices, scaffolds & carriers for cell delivery in nerve regeneration.
Matrices, scaffolds & carriers for cell delivery in nerve regeneration.
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DOI:
10.1016/j.expneurol.2018.09.020
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发表时间:
2019-09
影响因子:
5.3
通讯作者:
Sakiyama-Elbert SE
中科院分区:
文献类型:
--
作者:
Wang ZZ;Sakiyama-Elbert SE
Nerve injuries can be life-long debilitating traumas that severely impact patients’ quality of life. While many acellular neural scaffolds have been developed to aid the process of nerve regeneration, complete functional recovery is still very difficult to achieve, especially for long-gap peripheral nerve injury and most cases of spinal cord injury. Cell-based therapies have shown many promising results for improving nerve regeneration. With recent advances in neural tissue engineering, the integration of biomaterial scaffolds and cell transplantation are emerging as a more promising approach to enhance nerve regeneration. This review provides an overview of important considerations for designing cell-carrier biomaterial scaffolds. It also discusses current biomaterials used for scaffolds that provide permissive and instructive microenvironments for improved cell transplantation.
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DOI:
10.1523/jneurosci.3481-16.2017
发表时间:
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期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
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DOI:
10.1016/0304-4165(80)90335-9
发表时间:
1980-01-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子:
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STEPHEN, L