Antifouling Behavior of Copper-Modified Titania Nanotube Surfaces.
Antifouling Behavior of Copper-Modified Titania Nanotube Surfaces.
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DOI：
10.3390/jfb14080413
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发表时间：
2023-08-04
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
钛及其合金具有优良的机械性能、耐腐蚀性和生物相容性，常用于制造骨科植入物。近年来，整形外科植入手术已大大增加。这也导致这些植入物的感染相关翻修手术增加。为了解决这一问题，文献中正在研究各种方法。其中一种方法是修改植入物的表面形貌，并创建不仅可修复而且还能促进骨整合的表面。二氧化钛纳米管表面已经证明细菌粘附的适度减少，同时鼓励间充质干细胞粘附、增殖和分化，因此用于本研究。在这项工作中，二氧化钛纳米管表面制备使用一个简单的阳极氧化技术。使用物理气相沉积技术用铜进一步修饰这些表面，因为已知铜一旦接触就对细菌有效。在这项研究中，扫描电子显微镜被用来评估表面形貌;能量色散X射线光谱和X射线光电子能谱被用来评估表面化学;接触角测角法被用来评估表面润湿性;和X射线衍射被用来评估表面结晶度。对革兰氏阳性菌和革兰氏阴性菌的防污行为也进行了研究。结果表明，铜改性的二氧化钛纳米管表面表现出增强的抗菌行为相比，其他表面，这可能是一个潜在的方式，以防止感染的骨科植入物。
Titanium and its alloys are commonly used to fabricate orthopedic implants due to their excellent mechanical properties, corrosion resistance, and biocompatibility. In recent years, orthopedic implant surgeries have considerably increased. This has also resulted in an increase in infection-associated revision surgeries for these implants. To combat this, various approaches are being investigated in the literature. One of the approaches is modifying the surface topography of implants and creating surfaces that are not only antifouling but also encourage osteointegration. Titania nanotube surfaces have demonstrated a moderate decrease in bacterial adhesion while encouraging mesenchymal stem cell adhesion, proliferation, and differentiation, and hence were used in this study. In this work, titania nanotube surfaces were fabricated using a simple anodization technique. These surfaces were further modified with copper using a physical vapor deposition technique, since copper is known to be potent against bacteria once in contact. In this study, scanning electron microscopy was used to evaluate surface topography; energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy were used to evaluate surface chemistry; contact angle goniometry was used to evaluate surface wettability; and X-ray diffraction was used to evaluate surface crystallinity. Antifouling behavior against a gram-positive and a gram-negative bacterium was also investigated. The results indicate that copper-modified titania nanotube surfaces display enhanced antifouling behavior when compared to other surfaces, and this may be a potential way to prevent infection in orthopedic implants.
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影响因子：
14
作者：
Kommireddy, Dinesh S.;Sriram, Shashikanth M.;Mills, David K.
通讯作者：
Mills, David K.
影响因子：
8
作者：
Oliveira, Francilio Carvalho;Carvalho, Jancineide Oliveira;Lobo, Anderson Oliveira
通讯作者：
Lobo, Anderson Oliveira
影响因子：
8.2
作者：
Damiati L;Eales MG;Nobbs AH;Su B;Tsimbouri PM;Salmeron-Sanchez M;Dalby MJ
通讯作者：
Dalby MJ
影响因子：
4.9
作者：
DRANCOURT, M;STEIN, A;RAOULT, D
通讯作者：
RAOULT, D
影响因子：
2.1
作者：
Neufeld, Bella H.;Reynolds, Melissa M.
通讯作者：
Reynolds, Melissa M.