Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants.

Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants.
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DOI:
10.1177/2041731418790694
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发表时间:
2018-01
影响因子:
8.2
通讯作者:
Dalby MJ
Dalby MJ
中科院分区:
工程技术1区
文献类型:
--
作者:
Damiati L;Eales MG;Nobbs AH;Su B;Tsimbouri PM;Salmeron-Sanchez M;Dalby MJ

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钛(Ti)作为骨科和牙科植入物的首选材料发挥着主导作用。尽管大多数钛种植体具有长期成功,但由于骨结合不成功导致无菌性松动而导致的过早失效仍然太常见。最近,表面形貌改性和生物/非生物涂层已被整合到骨科/牙科植入物中,以模拟周围的生物环境并减少可能发生的炎症/感染。在这篇综述中,我们总结了各种钛涂层在体内和体外对细胞行为的影响。首先,我们专注于钛表面特性及其对骨生成的影响,然后对细菌的粘附和活力。我们从当前文献中得出结论,可以对钛植入物进行表面改性,从而提供骨诱导和抗菌性能。
Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.
纳米结构的钛表面表现出对葡萄球菌生物膜形成的顽固性。
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