Potential for acceleration of bone formation after implant surgery by using a dietary supplement: an animal study.
Potential for acceleration of bone formation after implant surgery by using a dietary supplement: an animal study.
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使用膳食补充剂加速种植手术后骨形成的潜力：一项动物研究。
DOI：
10.1111/joor.12270
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发表时间：
2015
影响因子：
2.9
通讯作者：
Y. Kawai
中科院分区：
文献类型：
--
作者：
Takehiro Watanabe;H. Nakada;Takahiro Takahashi;K. Fujita;Yasuhiro Tanimoto;Toshiro Sakae;Suguru Kimoto;Y. Kawai
种植牙治疗是恢复失去的美学和咀嚼功能的有效方式。然而，种植手术后的愈合至少需要3-6个月。这种延长的愈合期对具有大的缺牙区域的个体造成了一些困难，并降低了他们的生活质量。因此，缩短愈合期和加速术后最终假体放置在临床上非常重要。种植体周围骨形成可以通过全身方法来增强，例如使用骨质疏松补充剂，以促进骨代谢。为了确认摄入为骨质疏松症开发的补充剂，合成骨矿物质（SBM），是否能有效加速种植体周围骨形成，作为植入后愈合过程的一部分。将24只5周龄雌性Wistar大鼠随机分配至不含SBM（对照组，n = 12）或含SBM（n = 12）的标准化饮食。大鼠在8周龄时在全身麻醉下进行植入手术。主要结局指标为植入物和股骨的骨矿物质密度（BMD）和拔出强度，使用Mann-Whitney U检验在植入后2周和4周对两组进行比较。与对照组相比，SBM组在植入后2周和4周的BMD显著更高。与对照组相比，SBM组在植入后2周和4周的拔出强度显著更大。这项研究表明，SBM可以有效地促进种植体周围骨形成在种植后愈合期。
Dental implant treatment is an effective modality to restore lost aesthetic and masticatory functions. However, healing after implant surgery takes at least 3-6 months. This prolonged healing period poses several difficulties for individuals with a large edentulous area and decreases their quality of life. Consequently, shortening the healing period and accelerating final prosthesis placement after surgery is very clinically important. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. To confirm whether intake of a supplement developed for osteoporosis, synthetic bone mineral (SBM), was effective in accelerating peri-implant bone formation as part of the healing process after implantation. Twenty-four 5-week-old female Wistar rats were randomly assigned to receive a standardised diet without (control group, n = 12) or with SBM (n = 12). The rats had implant surgery at 8 weeks of age under general anaesthesia. The main outcome measures were bone mineral density (BMD) and pull-out strength in the implant and femur, which were compared between the groups at 2 and 4 weeks after implantation using the Mann-Whitney U test. BMD was significantly greater in the SBM group at 2 and 4 weeks after implantation compared to the control group. Pull-out strength was significantly greater in the SBM groups at 2 and 4 weeks after implantation compared to the control group. This study demonstrated that SBM could be effective in accelerating peri-implant bone formation during the healing period after implantation.
影响因子：
3.8
作者：
Otsuka, Makoto;Oshinbe, Ayako;Higuchi, William I.
通讯作者：
Higuchi, William I.
DOI：
10.1002/jbm.b.31277
发表时间：
2009-07
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Y. Tokudome;M. Otsuka;A. Ito;R. Legeros
通讯作者：
Y. Tokudome;M. Otsuka;A. Ito;R. Legeros
影响因子：
4.9
作者：
Yamada, Yasutaka;Ito, Astuo;LeGeros, Racquel Z.
通讯作者：
LeGeros, Racquel Z.