Activating brown adipose tissue for weight loss and lowering of blood glucose levels: a microPET study using obese and diabetic model mice.
Activating brown adipose tissue for weight loss and lowering of blood glucose levels: a microPET study using obese and diabetic model mice.
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激活棕色脂肪组织以减轻体重和降低血糖水平：使用肥胖和糖尿病模型小鼠进行的 MicroPET 研究。
DOI：
10.1371/journal.pone.0113742
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhu Z
中科院分区：
文献类型：
--
作者：
Wu C;Cheng W;Sun Y;Dang Y;Gong F;Zhu H;Li N;Li F;Zhu Z
本研究旨在利用18F-FDG microPET监测不同干预措施下肥胖和糖尿病小鼠模型的棕色脂肪组织（BAT）葡萄糖代谢，并研究BAT激活对这些模型的减肥和降血糖治疗潜力。通过高脂饮食8周建立肥胖小鼠模型，用链脲佐菌素诱导肥胖小鼠糖尿病（DM）模型。18F-FDG microPET用于监测肥胖和DM建模期间以及BRL 37344（β3-肾上腺素能受体激动剂）或左旋甲状腺素治疗后的BAT功能。BAT功能与体重、血糖水平相关。与对照组相比，肥胖小鼠和DM小鼠肩胛间BAT的18F-FDG摄取依次降低（P分别为0.036和<0.001）。 BRL 37344治疗两周后，肥胖小鼠（P = 0.010）和DM小鼠（P = 0.004）的BAT摄取均显著升高，同时血糖水平显著降低（分别为P=0.023和0.036）。 BAT摄取与肥胖小鼠（r =-0.71，P = 0.003）和DM小鼠（r =-0.74，P = 0.010）的血糖水平呈负相关。 BRL 37344治疗还在肥胖小鼠中引起显著的体重减轻（P = 0.001）。 左旋甲状腺素治疗增加了对照小鼠（P = 0.025）和肥胖小鼠（P = 0.013）的BAT摄取，但在DM小鼠中没有增加（P = 0.45）。 β3-肾上腺素能受体激动剂或甲状腺激素可以重新激活肥胖和DM小鼠中被抑制的BAT功能，有效的BAT激活可能导致体重减轻和血糖降低。激活BAT可以为肥胖和DM提供新的治疗策略。
This study aims at using 18F-FDG microPET to monitor the brown adipose tissue (BAT) glucose metabolism in obese and diabetic mouse models under different interventions, and study the therapeutic potential of BAT activation for weight loss and lowering of blood glucose in these models. Obese mice were established by a high-fat diet for eight weeks, and diabetes mellitus(DM) models were induced with Streptozocin in obese mice. 18F-FDG microPET was used to monitor BAT function during obese and DM modeling, and also after BRL37344 (a β3-adrenergic receptor agonist) or levothyroxine treatment. The BAT function was correlated with the body weight and blood glucose levels. Compared with the controls, the obese mice and DM mice showed successively lower 18F-FDG uptake in the interscapular BAT (P = 0.036 and <0.001, respectively). After two-week BRL37344 treatment, the BAT uptake was significantly elevated in both obese mice (P = 0.010) and DM mice (P = 0.004), accompanied with significantly decreased blood glucose levels (P = 0.023 and 0.036, respectively). The BAT uptake was negatively correlated with the blood glucose levels in both obese mice (r = −0.71, P = 0.003) and DM mice (r = −0.74, P = 0.010). BRL37344 treatment also caused significant weight loss in the obese mice (P = 0.001). Levothyroxine treatment increased the BAT uptake in the control mice (P = 0.025) and obese mice (P = 0.013), but not in the DM mice (P = 0.45). The inhibited BAT function in obese and DM mice can be re-activated by β3-adrenergic receptor agonist or thyroid hormone, and effective BAT activation may lead to weight loss and blood glucose lowering. Activating BAT can provide a new treatment strategy for obesity and DM.
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影响因子：
7.7
作者：
Sacks H;Symonds ME
通讯作者：
Symonds ME
人类中的棕色脂肪：调高肥胖症的热量。
影响因子：
7.7
作者：
Seale P;Lazar MA
通讯作者：
Lazar MA
影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
DOI：
10.1097/med.0b013e328337a81f
发表时间：
2010-04
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Cypess AM;Kahn CR
通讯作者：
Kahn CR
影响因子：
3.3
作者：
Masuo K;Lambert GW
通讯作者：
Lambert GW