In(s) and out(s) of adolescent depression - Trajectories of development and recovery.
In(s) and out(s) of adolescent depression - Trajectories of development and recovery.
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DOI：
10.1016/j.bbih.2021.100382
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Zajkowska Z
中科院分区：
文献类型：
--
作者：
Zajkowska Z
虽然生物标记物在了解成人严重抑郁障碍(MDD)方面的作用已被广泛研究，但对识别MDD在青春期发展和康复的生物标记物的研究较少。由于大多数精神健康障碍始于青春期，识别生命早期从MDD过渡和恢复的生物标记物对于制定有效的预防策略至关重要。考虑到大多数儿童和青少年人口来自低收入和中等收入国家，将重点放在这些环境中的青少年人口至关重要。由于大多数研究来自高收入国家(HIC)，有证据表明，早上皮质醇水平升高，包括皮质醇唤醒反应(CAR)、外周炎症增加和大脑异常，如皮质-边缘调节失调或奖励相关区域对积极信息的反应迟钝，与MDD有关，并有可能在青春期发生MDD。我们还发现，一些从MDD中恢复的生物学机制，主要是皮质-边缘调节失调的正常化，在心理治疗后被报道，这表明导致MDD脆弱性和恢复的共同路径。然而，只有几项研究包括青少年人群。了解心理干预有效的分子机制，以及高危个体向抑郁症过渡的分子标记物，对于制定有效的预防和干预策略非常重要。皮质醇和炎症升高，以及与大脑相关的异常与青少年抑郁症有关。心理治疗与抑郁症患者大脑区域的变化有关。在青少年人群中的研究数量很少，来自低收入和中等收入国家的研究很少。
While the role of biological markers in understanding major depressive disorder (MDD) in adults have been studied extensively, less has been done to identify the biomarkers of MDD development and recovery in adolescence. With the majority of mental health disorders starting in adolescence, identifying biomarkers of transition and recovery from MDD early in life is critical for developing effective prevention strategies. Considering most of the child and adolescent populations come from low-and-middle-income countries (LMICs), it is vital to focus on adolescent populations in these settings. With most studies coming from high-income countries (HICs), evidence suggests that elevated morning cortisol levels including cortisol awakening response (CAR), increased peripheral inflammation and brain abnormalities such as cortico-limbic dysregulation or blunted activity in reward related regions in response to positive information are associated with MDD and being at-risk for MDD development in adolescence. We also find that some of the biological mechanisms of recovery from MDD, mainly normalisation in the cortico-limbic dysregulation, are reported following psychological therapy, suggesting shared pathways leading to MDD vulnerability and recovery. Although, only a few studies include adolescent populations. Understanding molecular mechanisms through which psychological interventions are effective, as well as molecular markers of transition to depression in individuals at-risk, are important to inform effective prevention and intervention strategies. Elevated cortisol and inflammation, and brain related abnormalities are linked with adolescent depression. Psychological therapy is linked with changes in the brain areas present in depression. Low number of studies in adolescent populations, with very few from low-and-middle income countries (LMICs).
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影响因子：
6.6
作者：
Gabbay, Vilma;Klein, Rachel G.;Alonso, Carmen M.;Babb, James S.;Nishawala, Melissa;De Jesus, Georgette;Hirsch, Glenn S.;Hottinger-Blanc, Pauline M. Z.;Gonzalez, Charles J.
通讯作者：
Gonzalez, Charles J.
影响因子：
5.3
作者：
Cattaneo A;Macchi F;Plazzotta G;Veronica B;Bocchio-Chiavetto L;Riva MA;Pariante CM
通讯作者：
Pariante CM
DOI：
10.1097/00004583-199406000-00008
发表时间：
1994-06-01
影响因子：
13.3
作者：
BIRMAHER, B;RABIN, BS;RYAN, ND
通讯作者：
RYAN, ND
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
11
作者：
Baumeister D;Akhtar R;Ciufolini S;Pariante CM;Mondelli V
通讯作者：
Mondelli V