Immune system dysregulation in adolescent major depressive disorder.
Immune system dysregulation in adolescent major depressive disorder.
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DOI：
10.1016/j.jad.2008.07.022
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发表时间：
2009-05
影响因子：
6.6
通讯作者：
Gonzalez, Charles J.
中科院分区：
文献类型：
--
作者：
Gabbay, Vilma;Klein, Rachel G.;Alonso, Carmen M.;Babb, James S.;Nishawala, Melissa;De Jesus, Georgette;Hirsch, Glenn S.;Hottinger-Blanc, Pauline M. Z.;Gonzalez, Charles J.
大量证据表明，免疫系统失调与成人重度抑郁症 (MDD) 相关。本研究将这项工作扩展到青少年 MDD，以检验患有 MDD 的青少年免疫系统失调的假设，其显着表现为：（i）血浆细胞因子水平升高（干扰素 [IFN]-γ、肿瘤坏死因子-α、白细胞介素 [IL]-6、IL-1β 和 IL-4）； (ii) Th1/Th2 细胞因子失衡转向 Th1，如 IFN-γ/IL-4 增加所示。纳入了 30 名患有 MDD 的青少年（19 名女性；13 名未用药/未用药；12-19 岁），病程至少为 6 周，并且儿童抑郁评定量表（修订版）的最低严重程度评分为 40 分；另外还有 15 名年龄匹配的健康对照者（8 名女性）。使用酶联免疫吸附测定法检查血浆细胞因子。曼-惠特尼检验用于比较患有 MDD 的受试者和对照组。患有 MDD 的青少年血浆 IFN-γ 水平显着升高（3.38 ± 11.8 pg/ml 对比 0.37 ± 0.64 pg/ml；p<0.003），以及 IFN-γ/IL-4 比率（16.6 ± 56.5 对比 1.76 ± 2.28；p = 0.007）。 MDD 组中还观察到 IL-6 升高的趋势（1.52 ± 2.88 pg/ml 对比 0.49 ± 0.90 pg/ml；p=0.09）。重要的是，当排除用药受试者后，结果仍然很明显。研究结果表明，免疫系统失调可能与青少年 MDD 有关，正如成人 MDD 中所记录的那样，Th1/Th2 的不平衡转向 Th1。随后应该对未服药的青少年进行更大规模的研究。
A large body of evidence suggests that immune system dysregulation is associated with Major Depressive Disorder (MDD) in adults. This study extends this work to adolescent MDD to examine the hypotheses of immune system dysregulation in adolescents with MDD, as manifested by significantly: (i) elevated plasma levels of cytokines (interferon [IFN]-γ, tumor necrosis factor-α, interleukin [IL]-6, IL-1β, and IL-4); and (ii) Th1/Th2 cytokine imbalance shifted toward Th1 as indexed by increased IFN-γ/IL-4. Thirty adolescents with MDD (19 females; 13 medication-free/naïve; ages 12–19) of at least 6 weeks duration and a minimum severity score of 40 on the Children’s Depression Rating Scale—Revised, and 15 healthy comparisons (8 females), group-matched for age, were enrolled. Plasma cytokines were examined using enzyme-linked immunosorbent assay. Mann–Whitney test was used to compare subjects with MDD and controls. Adolescents with MDD had significantly elevated plasma IFN-γ levels (3.38 ± 11.8 pg/ml versus 0.37 ± 0.64 pg/ml; p<0.003), and IFN-γ/IL-4 ratio (16.6 ± 56.5 versus 1.76 ± 2.28; p = 0.007). A trend for IL-6 to be elevated in the MDD group was also observed (1.52 ± 2.88 pg/ml versus 0.49 ± 0.90 pg/ml; p=0.09). Importantly, findings remained evident when medicated subjects were excluded. Findings suggest that immune system dysregulation may be associated with adolescent MDD, with an imbalance of Th1/Th2 shifted toward Th1, as documented in adult MDD. Larger studies with medication-free adolescents should follow.
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影响因子：
15.1
作者：
Pollmächer, T;Haack, M;Yirmiya, R
通讯作者：
Yirmiya, R
影响因子：
158.5
作者：
Musselman, DL;Lawson, DH;Miller, AH
通讯作者：
Miller, AH
影响因子：
11.9
作者：
Huang, Tiao-Lai;Lee, Chien-Te
通讯作者：
Lee, Chien-Te
DOI：
10.1097/00004583-199406000-00008
发表时间：
1994-06-01
影响因子：
13.3
作者：
BIRMAHER, B;RABIN, BS;RYAN, ND
通讯作者：
RYAN, ND
影响因子：
8
作者：
Goodman, E;Whitaker, RC
通讯作者：
Whitaker, RC