Non-invasive estimation of metabolic flux and blood flow in working muscle: effect of blood-tissue distribution.
Non-invasive estimation of metabolic flux and blood flow in working muscle: effect of blood-tissue distribution.
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DOI：
10.1007/978-0-387-85998-9_24
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发表时间：
2009
影响因子：
--
通讯作者：
Cabrera, Marco E.
中科院分区：
文献类型：
--
作者：
Lai, Nicola;Saidel, Gerald M.;Iorio, Matthew;Cabrera, Marco E.
肌肉氧合测量近红外光谱（NIRS）经常在人类中获得的工作骨骼肌呼吸代谢控制机制的推断。然而，这些测量具有技术局限性，可能会误导组织过程的评价。特别地，工作肌肉的NIRS测量代表具有异质激活、灌注和结构的纤维混合物的氧合。具体而言，毛细血管、小动脉和小静脉的相对体积分布可能影响NIRS数据。为研究工作肌各组成部分的空间体积分布对氧利用动力学和血流变化的影响，建立了氧运输和利用的数学模型。该模型包括骨骼肌内的血容量分布，并考虑了工作肌中氧运输和代谢的对流、扩散和反应过程。模型的输入是动脉O2浓度、心输出量和ATP需求。模型模拟进行了比较，从人类受试者的运动数据在休息到工作的过渡。分析了肌肉耗氧量、血流量和毛细血管-组织转运速率系数之间的关系。肌肉中的血容量分布对响应于运动刺激的代谢通量和血流量的最佳估计具有显著影响。
Muscle oxygenation measurements by near infrared spectroscopy (NIRS) are frequently obtained in humans to make inferences about mechanisms of metabolic control of respiration in working skeletal muscle. However, these measurements have technical limitations that can mislead the evaluation of tissue processes. In particular, NIRS measurements of working muscle represent oxygenation of a mix of fibers with heterogeneous activation, perfusion and architecture. Specifically, the relative volume distribution of capillaries, small arteries, and venules may affect NIRS data. To determine the effect of spatial volume distribution of components of working muscle on oxygen utilization dynamics and blood flow changes, a mathematical model of oxygen transport and utilization was developed. The model includes blood volume distribution within skeletal muscle and accounts for convective, diffusive, and reactive processes of oxygen transport and metabolism in working muscle. Inputs to the model are arterial O2 concentration, cardiac output and ATP demand. Model simulations were compared to exercise data from human subjects during a rest-to-work transition. Relationships between muscle oxygen consumption, blood flow, and the rate coefficient of capillary-tissue transport are analyzed. Blood volume distribution in muscle has noticeable effects on the optimal estimates of metabolic flux and blood flow in response to an exercise stimulus.
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影响因子：
3
作者：
Lai, N.;Dash, R. K.;Cabrera, M. E.
通讯作者：
Cabrera, M. E.
影响因子：
3.8
作者：
Lai, Nicola;Camesasca, Marco;Cabrera, Marco E.
通讯作者：
Cabrera, Marco E.
DOI：
10.1034/j.1600-0838.2001.110404.x
发表时间：
2001-08-01
影响因子：
4.1
作者：
Boushel, R;Langberg, H;Kjær, M
通讯作者：
Kjær, M
DOI：
10.1046/j.1365-201x.2000.00710.x
发表时间：
2000-04-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Pittman, RN
通讯作者：
Pittman, RN
DOI：
10.1152/ajpregu.1999.276.6.r1682
发表时间：
1999-06-01
影响因子：
2.8
作者：
Tran, TK;Sailasuta, N;Jue, T
通讯作者：
Jue, T