Encephalomyocarditis virus-induced diabetes mellitus in mice: model of viral pathogenesis.
Encephalomyocarditis virus-induced diabetes mellitus in mice: model of viral pathogenesis.
复制标题
脑心肌炎病毒诱发的小鼠糖尿病：病毒发病机制模型。
DOI：
10.1093/clinids/9.5.917
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
S. Cohen
中科院分区：
文献类型：
--
作者：
G. Jordan;S. Cohen
Encephalomyocarditis (EMC) virus induction of diabetes mellitus in mice has proven to be an excellent experimental model for the pathogenesis of viral disease. In SJL and DBA/2 mice, diabetes results exclusively from the infection and damage of beta cells by the virus. In addition, in BALB/cBy mice subclinical beta cell damage caused by the virus is followed by autoimmune beta cell destruction, which results in hyperglycemia. Studies of two closely related plaque variants (EMC-D and EMC-B) selected from the M strain of EMC virus revealed differences in the interferon response associated with viral infection. The EMC-D variant causes diabetes in infected SJL mice by direct beta cell destruction. Infection with EMC-B does not cause diabetes and interferes with the production of diabetes by EMC-D due to the greater ability of EMC-B than of EMC-D to induce interferon in mice. Circulating interferon has a greater effect on inhibition of viral replication because local interferon production is amplified in interferon-primed cells infected with EMC-B. These properties are determined by the interferon-inducing particle (Ifp+) phenotype of EMC-B and the Ifp- phenotype of EMC-D.
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DOI：
10.1056/nejm198605223142106
发表时间：
1986-05
期刊：
The New England Journal of Medicine
影响因子：
--
作者：
G. Eisenbarth
通讯作者：
G. Eisenbarth
干扰素诱导剂抑制病毒诱导的小鼠糖尿病。
DOI：
10.1089/jir.1982.2.59
发表时间：
1982
期刊：
Journal of interferon research
影响因子：
--
作者：
Gadzik,JP;Naji,A;Barker,CF;Blank,KJ
通讯作者：
Blank,KJ
DOI：
10.1089/jir.1982.2.511
发表时间：
1982
期刊：
Journal of interferon research
影响因子：
--
作者：
Marcus,PI
通讯作者：
Marcus,PI
DOI：
10.1089/jir.1981.1.601
发表时间：
1981
期刊：
Journal of interferon research
影响因子：
--
作者：
Marcus,PI;GuidonJr,PT;Sekellick,MJ
通讯作者：
Sekellick,MJ
病毒性糖尿病的免疫学。
DOI：
10.1159/000156960
发表时间：
1985
期刊：
Survey and synthesis of pathology research
影响因子：
--
作者：
Babu,PG;Huber,SA;Craighead,JE
通讯作者：
Craighead,JE