Surgical Menopause and Estrogen Therapy Modulate the Gut Microbiota, Obesity Markers, and Spatial Memory in Rats.
Surgical Menopause and Estrogen Therapy Modulate the Gut Microbiota, Obesity Markers, and Spatial Memory in Rats.
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手术更年期和雌激素治疗调节大鼠的肠道菌群，肥胖标志物和空间记忆。
DOI：
10.3389/fcimb.2021.702628
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发表时间：
2021
影响因子：
5.7
通讯作者：
Krajmalnik-Brown R
中科院分区：
文献类型：
--
作者：
Zeibich L;Koebele SV;Bernaud VE;Ilhan ZE;Dirks B;Northup-Smith SN;Neeley R;Maldonado J;Nirmalkar K;Files JA;Mayer AP;Bimonte-Nelson HA;Krajmalnik-Brown R
人类女性更年期和随后的卵巢激素缺乏，特别是17β-雌二醇(17-雌二醇，E2)的缺乏，增加了与肥胖、2型糖尿病、心血管疾病和痴呆症相关的代谢功能障碍的风险。几项研究表明，这些疾病也与肠道微生物区系的组成变化密切相关；然而，E2缺乏和激素治疗如何影响肠道微生物群落尚不清楚。使用大鼠模型，我们的目标是评估卵巢切除(OVX)和随后的E2注射如何推动代谢健康和肠道微生物群落的变化，以及与学习和记忆的潜在关联。结果表明，OVX诱导的卵巢激素缺乏和E2治疗对几个影响健康的参数有显著影响，包括：(A)某些肠道细菌分类群(如双歧杆菌科和卟啉单胞菌科)的丰富，(B)微生物短链脂肪酸(SCFA)的丰富(如异丁酸酯)，(C)体重/体重指数，以及(D)手术绝经后对空间工作记忆的高要求。此外，肠道细菌丰度、认知和BMI之间的探索性相关性强调了外科绝经和给予E2对肠道-大脑相互作用的推定影响。总体而言，这项研究表明，外科更年期与生理和行为变化有关，肠道微生物区系中与E2相关的成分变化可能导致其一些相关的负面健康后果。总体而言，这项研究为绝经后生命阶段内分泌和胃肠系统之间的相互作用提供了新的见解，这些系统共同改变了心血管、代谢和痴呆症相关疾病的发展和进展的风险。
Menopause in human females and subsequent ovarian hormone deficiency, particularly concerning 17β-estradiol (E2), increase the risk for metabolic dysfunctions associated with obesity, diabetes type 2, cardiovascular diseases, and dementia. Several studies indicate that these disorders are also strongly associated with compositional changes in the intestinal microbiota; however, how E2 deficiency and hormone therapy affect the gut microbial community is not well understood. Using a rat model, we aimed to evaluate how ovariectomy (OVX) and subsequent E2 administration drive changes in metabolic health and the gut microbial community, as well as potential associations with learning and memory. Findings indicated that OVX-induced ovarian hormone deficiency and E2 treatment had significant impacts on several health-affecting parameters, including (a) the abundance of some intestinal bacterial taxa (e.g., Bifidobacteriaceae and Porphyromonadaceae), (b) the abundance of microbial short-chain fatty acids (SCFAs) (e.g., isobutyrate), (c) weight/BMI, and (d) high-demand spatial working memory following surgical menopause. Furthermore, exploratory correlations among intestinal bacteria abundance, cognition, and BMI underscored the putative influence of surgical menopause and E2 administration on gut-brain interactions. Collectively, this study showed that surgical menopause is associated with physiological and behavioral changes, and that E2-linked compositional changes in the intestinal microbiota might contribute to some of its related negative health consequences. Overall, this study provides novel insights into interactions among endocrine and gastrointestinal systems in the post-menopausal life stage that collectively alter the risk for the development and progression of cardiovascular, metabolic, and dementia-related diseases.
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影响因子：
3
作者：
Bernaud VE;Hiroi R;Poisson ML;Castaneda AJ;Kirshner ZZ;Gibbs RB;Bimonte-Nelson HA
通讯作者：
Bimonte-Nelson HA
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
4.2
作者：
Bimonte, HA;Nelson, ME;Granholm, ACE
通讯作者：
Granholm, ACE
影响因子：
82.9
作者：
Depommier, Clara;Everard, Amandine;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
影响因子：
15.5
作者：
Bogatyrev, Said R.;Rolando, Justin C.;Ismagilov, Rustem F.
通讯作者：
Ismagilov, Rustem F.