Age Impacts the Burden That Reference Memory Imparts on an Increasing Working Memory Load and Modifies Relationships With Cholinergic Activity.
Age Impacts the Burden That Reference Memory Imparts on an Increasing Working Memory Load and Modifies Relationships With Cholinergic Activity.
复制标题
DOI：
10.3389/fnbeh.2021.610078
复制
发表时间：
2021
影响因子：
3
通讯作者：
Bimonte-Nelson HA
中科院分区：
文献类型：
--
作者：
Bernaud VE;Hiroi R;Poisson ML;Castaneda AJ;Kirshner ZZ;Gibbs RB;Bimonte-Nelson HA
啮齿动物衰老研究经常使用空间迷宫，如水径向臂迷宫（WRAM），以评估认知。WRAM可以同时测量空间工作记忆和参考记忆，其中这两种记忆类型通常被表示为正交的。然而，有证据表明，这两种记忆形式在高工作记忆负荷时会产生干扰。目前的研究系统地评估了参考记忆成分的存在是否会影响处理不断增加的工作记忆负荷。对年轻和年老的雌性大鼠进行了测试，以评估衰老是否会影响这种关系。从基底前脑到海马和皮质的胆碱能投射可以影响认知结果，并且受到衰老的负面影响。为了评估工作记忆和参考记忆的年龄相关变化是否与胆碱能功能有关，我们评估了这些行为测试大鼠的胆碱乙酰转移酶活性。结果表明，在一项只测试工作记忆的任务中，年轻大鼠的表现优于老年大鼠。添加参考记忆成分会降低处理不断增加的工作记忆负荷的能力，因此年轻大鼠的表现与老年大鼠相似。老年大鼠也有挑战时，参考记忆存在，但在不同的背景下。具体来说，与年轻大鼠相比，老年大鼠很难记住他们在一次会议中进入的参考记忆臂。此外，当工作记忆需求很高时，在参考记忆方面表现出色的老年大鼠在工作记忆方面也表现出色，这种关系在年轻大鼠中没有发现。胆碱能活性和迷宫性能之间的关系不同的方向和大脑区域的年龄，反映了复杂的作用，胆碱能系统在记忆和注意力的过程中，在整个女性的寿命。总体而言，添加参考记忆要求会在精神上影响处理年轻和老年时间点工作记忆信息的能力，特别是当工作记忆挑战很高时;这些与年龄相关的缺陷在添加参考记忆组件时表现不同。工作记忆和参考记忆之间的这种相互作用提供了对解决复杂认知任务所需的多个领域的洞察，可能会提高对年龄和疾病相关记忆失败复杂性的理解，并优化其各自的治疗方法。
Rodent aging research often utilizes spatial mazes, such as the water radial-arm-maze (WRAM), to evaluate cognition. The WRAM can simultaneously measure spatial working and reference memory, wherein these two memory types are often represented as orthogonal. There is evidence, however, that these two memory forms yield interference at a high working memory load. The current study systematically evaluated whether the presence of a reference memory component impacts handling of an increasing working memory load. Young and aged female rats were tested to assess whether aging impacts this relationship. Cholinergic projections from the basal forebrain to the hippocampus and cortex can affect cognitive outcomes, and are negatively impacted by aging. To evaluate whether age-related changes in working and reference memory profiles are associated with cholinergic functioning, we assessed choline acetyltransferase activity in these behaviorally-tested rats. Results showed that young rats outperformed aged rats on a task testing solely working memory. The addition of a reference memory component deteriorated the ability to handle an increasing working memory load, such that young rats performed similar to their aged counterparts. Aged rats also had challenges when reference memory was present, but in a different context. Specifically, aged rats had difficulty remembering which reference memory arms they had entered within a session, compared to young rats. Further, aged rats that excelled in reference memory also excelled in working memory when working memory demand was high, a relationship not seen in young rats. Relationships between cholinergic activity and maze performance differed by age in direction and brain region, reflecting the complex role that the cholinergic system plays in memory and attentional processes across the female lifespan. Overall, the addition of a reference memory requirement detrimentally impacted the ability to handle working memory information across young and aged timepoints, especially when the working memory challenge was high; these age-related deficits manifested differently with the addition of a reference memory component. This interplay between working and reference memory provides insight into the multiple domains necessary to solve complex cognitive tasks, potentially improving the understanding of complexities of age- and disease- related memory failures and optimizing their respective treatments.
登录
查看更多内容
影响因子：
4.2
作者：
Bimonte, HA;Nelson, ME;Granholm, ACE
通讯作者：
Granholm, ACE
影响因子：
4.8
作者：
Braden, B. Blair;Kingston, Melissa L.;Bimonte-Nelson, Heather A.
通讯作者：
Bimonte-Nelson, Heather A.
DOI：
10.1037/h0081022
发表时间：
1980-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
BARNES, CA;NADEL, L;HONIG, WK
通讯作者：
HONIG, WK
DOI：
10.1037/h0077579
发表时间：
1979-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, CA
通讯作者：
BARNES, CA
DOI：
10.1093/jnen/59.4.308
发表时间：
2000-04-01
影响因子：
3.2
作者：
Beach, TG;Kuo, YM;Roher, AE
通讯作者：
Roher, AE