Astrocyte proliferation following stroke in the mouse depends on distance from the infarct.
Astrocyte proliferation following stroke in the mouse depends on distance from the infarct.
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DOI：
10.1371/journal.pone.0027881
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Giffard RG
中科院分区：
文献类型：
--
作者：
Barreto GE;Sun X;Xu L;Giffard RG
反应性神经胶质增生是脑病理学和损伤反应的标志，但星形胶质细胞增殖的程度以及这是否是星形胶质细胞增生的核心仍然存在争议。我们使用无偏立体学确定了小鼠中风模型中增殖的成熟星形胶质细胞的分数，作为距梗塞边缘距离的函数。中风后第一周，皮质半暗带 400 µm 内的 Aldh1l1+ 星形胶质细胞累计有 11.1±1.2% 掺入 BrdU，而星形胶质细胞的总数没有变化。增殖的星形胶质细胞数量随着距离的增加而急剧下降，超过一半的增殖星形胶质细胞位于梗塞边缘 100 µm 范围内。尽管在中风后一周内主要是小胶质细胞和中性粒细胞/单核细胞广泛的细胞增殖，但很少有成熟的星形胶质细胞重新进入细胞周期，并且这些细胞集中在梗塞边界附近。
Reactive gliosis is a hallmark of brain pathology and the injury response, yet the extent to which astrocytes proliferate, and whether this is central to astrogliosis is still controversial. We determined the fraction of mature astrocytes that proliferate in a mouse stroke model using unbiased stereology as a function of distance from the infarct edge. Cumulatively 11.1±1.2% of Aldh1l1+ astrocytes within 400 µm in the cortical penumbra incorporate BrdU in the first week following stroke, while the overall number of astrocytes does not change. The number of astrocytes proliferating fell sharply with distance with more than half of all proliferating astrocytes found within 100 µm of the edge of the infarct. Despite extensive cell proliferation primarily of microglia and neutrophils/monocytes in the week following stroke, few mature astrocytes re-enter cell cycle, and these are concentrated close to the infarct boundary.
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