Twenty Years on for The Epithelial-Mesenchymal Transition International Association (TEMTIA): An Interview with Co-Founders Erik Thompson and Donald Newgreen
Twenty Years on for The Epithelial-Mesenchymal Transition International Association (TEMTIA): An Interview with Co-Founders Erik Thompson and Donald Newgreen
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国际上皮间充质转化协会 (TEMTIA) 二十周年：联合创始人埃里克·汤普森 (Erik Thompson) 和唐纳德·纽格林 (Donald Newgreen) 访谈
DOI：
10.1159/000518250
复制
发表时间：
2021
影响因子：
2.7
通讯作者：
Denker Hans-Werner
中科院分区：
文献类型：
--
作者：
Sheng Guojun;Thompson Erik;Newgreen Donald;Denker Hans-Werner
上皮-间充质转化（epithelial-mesenchymal transition， EMT）研究成立50多年来，一直受到发育生物学家、细胞生物学家和癌症生物学家之间跨学科互动的推动。其中，两位澳大利亚科学家——癌症生物学家埃里克·汤普森（Erik Thompson）和发育生物学家唐纳德·纽格林（Donald Newgreen）——在引导这个研究界走向目前的全盛状态方面发挥了重要作用。他们共同创立了“EMT国际协会”（TEMTIA），共同组织了第一次TEMTIA会议，汇集了不同背景的研究人员，尽管他们在科学方法上存在分歧，但他们共同倡导需要在基于EMT的治疗干预方面取得突破性发现，以对抗癌症。在早期，EMT研究也引起了德国发育生物学家汉斯-维尔纳·登克的注意。作为《细胞组织器官》（以前称为《解剖学报》）的主编，Denker博士在1995/1996年推动出版了两卷EMT专题专刊，巩固了EMT作为一门强大研究学科的地位。许多为第一期EMT特刊做出贡献的人以及参加第一次TEMTIA会议的人都成为了EMT研究的领导者和强有力的倡导者。在这次采访中，汤普森博士和纽格林博士回顾了他们自己和EMT的职业轨迹，并就该领域的发展方向提出了建议，同时还听取了丹克尔博士的评论。希望新一代的EMT研究人员，不那么害怕跨越学科界限，将为发展和疾病中的复杂生物现象带来概念上的清晰，基于EMT的和实验上可行的。
BackgroundFor more than 50 years after its inception, epithelial-mesenchymal transition (EMT) research has been catalyzed by cross-disciplinary interactions between developmental, cell, and cancer biologists. Among those, two Australian scientists, Erik Thompson, a cancer biologist, and Donald Newgreen, a developmental biologist, played an instrumental role in steering this research community towards its current state of full blossom. They co-founded “The EMT International Association”(TEMTIA), co-organized the first TEMTIA meeting, bringing together researchers of different background, and despite divergence in their scientific approaches, they have been co-advocating the need for breakthrough discoveries on EMT-based therapeutic intervention in fighting cancer. In its early days, EMT research also caught the attention of Hans-Werner Denker, a German developmental biologist. Through his role as Editor-in-Chief of Cells Tissues Organs (formerly known as Acta Anatomica), Dr. Denker pushed for the publication of a two-volume EMT-focused special topic issue in 1995/1996, consolidating the status of EMT as a formidable research discipline. Many of those who contributed to that first EMT special issue and who attended the first TEMTIA meeting became leaders and strong advocates of EMT research. In this interview, Dr. Thompson and Dr. Newgreen reminisce about their own career trajectories and about that of EMT, and offer advice on where this field should be heading, together with comments from Dr. Denker. The hope is that new generations of EMT researchers, less afraid of crossing disciplinary boundaries, will bring conceptual clarity, EMT-based and experimentally actionable, to complex biological phenomena in development and disease.
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DOI：
10.1159/000147748
发表时间：
1995
期刊：
Acta anatomica
影响因子：
--
作者：
E. Hay
通讯作者：
E. Hay
控制禽类胚胎中神经嵴细胞迁移的开始
影响因子：
3.6
作者：
Donald F. Newgreen;D. Gooday
通讯作者：
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影响因子：
2.7
作者：
Donald F. Newgreen;J. Minichiello
通讯作者：
J. Minichiello
抑制非典型蛋白激酶-C诱导鹌鹑胚胎神经细胞上皮间质转化
影响因子：
3.6
作者：
J. Minichiello;A. Ben;C. Hearn;B. Needham;D. Newgreen
通讯作者：
D. Newgreen
控制家禽胚胎中神经嵴细胞迁移开始时间的因素
影响因子：
3.6
作者：
D. Newgreen;I. Gibbins
通讯作者：
I. Gibbins