The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.
The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.
复制标题
中草药降低血清尿酸水平的功效和机制：系统评价。
DOI：
10.3389/fphar.2020.578318
复制
发表时间：
2020
影响因子：
5.6
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Chen L;Luo Z;Wang M;Cheng J;Li F;Lu H;He Q;You Y;Zhou X;Kwan HY;Zhao X;Zhou L
背景资料。中草药被广泛用于降低血清尿酸水平。然而，没有系统的审查总结和评估它们的有效性和潜在的作用机制。目标。目的：评价中草药降低血尿酸水平的临床和实验证据及其可能机制。方法：研究方法。使用PubMed、Wed of Science、Cochrane Library和Embase四个电子数据库搜索中草药在降低血尿酸水平方面的作用，时间为2009年1月1日至2020年8月19日。对于临床试验，纳入随机对照试验(RCT)；对于实验研究，纳入原始文章。根据Cochrane标准评价随机对照试验的方法学质量。对于临床试验，使用了对连续变量的荟萃分析来获得汇集效应。对于实验研究，使用列表来总结和整合所涉及的机制。结果。共纳入10项临床试验和184项实验研究。目前的数据显示，对于血尿酸水平升高的患者，中药具有良好的临床疗效(SMD：−1.65，95%CI：−3.09至−0.22；P=0.024)。中药组与西药组的血尿酸水平差异无统计学意义(−为0.13，95%CI：−为0.99~0.74，P=0.772)。实验研究表明，尿酸合成、尿酸转运、炎症、肾间质纤维化和氧化应激等信号转导通路参与了血尿酸的降低作用。结论。临床研究表明，中草药可降低血尿酸水平。具有复杂研究设计的进一步研究可以进一步证明这些中草药在降低血尿酸水平方面的有效性和安全性，并揭示其潜在作用机制的全面图景。
Background. Chinese herbal medicines are widely used to lower serum uric acid levels. However, no systemic review summarizes and evaluates their efficacies and the underlying mechanisms of action. Objectives. To evaluate the clinical and experimental evidences for the effectiveness and the potential mechanism of Chinese herbal medicines in lowering serum uric acid levels. Methods. Four electronic databases PubMed, Wed of Science, the Cochrane Library and Embase were used to search for Chinese herbal medicines for their effects in lowering serum uric acid levels, dated from 1 January 2009 to 19 August 2020. For clinical trials, randomized controlled trials (RCTs) were included; and for experimental studies, original articles were included. The methodological quality of RCTs was assessed according to the Cochrane criteria. For clinical trials, a meta-analysis of continuous variables was used to obtain pooled effects. For experimental studies, lists were used to summarize and integrate the mechanisms involved. Results. A total of 10 clinical trials and 184 experimental studies were included. Current data showed that Chinese herbal medicines have promising clinical efficacies in patients with elevated serum uric acid levels (SMD: −1.65, 95% CI: −3.09 to −0.22; p = 0.024). There was no significant difference in serum uric acid levels between Chinese herbal medicine treatments and Western medicine treatments (SMD: −0.13, 95% CI: −0.99 to 0.74; p = 0.772). Experimental studies revealed that the mechanistic signaling pathways involved in the serum uric acid lowering effects include uric acid synthesis, uric acid transport, inflammation, renal fibrosis and oxidative stress. Conclusions. The clinical studies indicate that Chinese herbal medicines lower serum uric acid levels. Further studies with sophisticated research design can further demonstrate the efficacy and safety of these Chinese herbal medicines in lowering serum uric acid levels and reveal a comprehensive picture of the underlying mechanisms of action.
登录
查看更多内容
影响因子：
4.8
作者：
Anzai, Naohiko;Ichida, Kimiyoshi;Sakurai, Hiroyuki
通讯作者：
Sakurai, Hiroyuki
影响因子：
4.6
作者：
Chen Yu-Sheng;Chen Chao-Jun;Kong Ling-Dong
通讯作者：
Kong Ling-Dong
薯蓣总皂苷通过上调 OATP1A1 降低高尿酸血症大鼠的血清尿酸水平
DOI：
10.1007/s11596-016-1573-z
发表时间：
2016-04-01
影响因子：
--
作者：
Chen, Yan;Chen, Xiao-lin;Wang, Chang-jun
通讯作者：
Wang, Chang-jun
影响因子：
2.9
作者：
Chen Qian;Ma Li;Wupu, Akebaier
通讯作者：
Wupu, Akebaier
影响因子：
--
作者：
Amat N;Umar A;Hoxur P;Anaydulla M;Imam G;Aziz R;Upur H;Kijjoa A;Moore N
通讯作者：
Moore N