A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women.
A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women.
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DOI：
10.1038/s41598-022-17800-0
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发表时间：
2022-08-08
影响因子：
4.6
通讯作者：
Terry, Mary Beth
中科院分区：
文献类型：
--
作者：
Kehm, Rebecca D.;Walter, E. Jane;Pereira, Ana;White, Melissa L.;Oskar, Sabine;Michels, Karin B.;Shepherd, John A.;Lilge, Lothar;Terry, Mary Beth
本研究比较了测量智利圣地亚哥一个队列中的青春期女孩（n = 42，年龄14 - 16岁）及其母亲（n = 39，年龄36 - 61岁）的乳腺密度和乳腺组织成分（BTC）的不同方法。光谱学（OS）用于测量胶原蛋白、水和脂质浓度，这些浓度被合并为一个乳腺密度百分比指数（%BDI）。一个经过校准用于测量乳腺密度的临床双能X线吸收法（DXA）系统从手动描绘的图像中提供纤维腺体体积百分比（%FGV）。在将乳腺X线照片数字化之后，使用计算机辅助软件测量乳腺X线摄影乳腺密度百分比（%MBD）。偏相关系数（rpartial）用于评估这三种不同测量方法得出的乳腺密度测量值与BTC之间的关联，并根据年龄和体重指数进行调整。在青春期女孩中，光谱学得出的%BDI与双能X线吸收法得出的%FGV相关（rpartial = 0.46，p值 = 0.003），但在母亲中不相关（rpartial = 0.17，p值 = 0.32）。在母亲中，双能X线吸收法得出的%FGV与乳腺X线照片得出的%MBD相关（rpartial = 0.60，p值 < 0.001）。这些发现表明，来自光谱学、双能X线吸收法和乳腺X线照片的数据提供了有关乳腺密度和乳腺组织成分的相关但不同的信息。未来的研究应该探索如何将这些不同设备提供的信息用于青春期女孩和女性队列的乳腺癌风险预测。
This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients (rpartial) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls (rpartial = 0.46, p-value = 0.003), but not in mothers (rpartial = 0.17, p-value = 0.32). In mothers, %FGV from DXA was associated with %MBD from mammograms (rpartial = 0.60, p-value < 0.001). These findings suggest that data from OS, DXA, and mammograms provide related but distinct information about breast density and BTC. Future studies should explore how the information provided by these different devices can be used for breast cancer risk prediction in cohorts of adolescent girls and women.
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影响因子：
3.8
作者：
Blackmore, Kristina M.;Knight, Julia A.;Lilge, Lothar
通讯作者：
Lilge, Lothar
影响因子：
6.9
作者：
Kain, Juliana;Corvalan, Camila;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
3.7
作者：
Taroni, Paola;Quarto, Giovanna;Cubeddu, Rinaldo
通讯作者：
Cubeddu, Rinaldo
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ