Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma.
Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma.
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DOI：
10.1016/j.ajo.2021.05.012
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发表时间：
2021-11
影响因子：
4.2
通讯作者：
Richter GM
中科院分区：
文献类型：
--
作者：
Phillips MJ;Dinh-Dang D;Bolo K;Burkemper B;Lee JC;LeTran VH;Chang BR;Grisafe DJ;Chu Z;Zhou X;Song BJ;Xu BY;Wong B;Wang RK;Richter GM
比较复杂的基于信号的光学微血管造影 (OMAGC) 光学相干断层扫描血管造影 (OCTA) 设备的青光眼周围毛细血管和黄斑指标测量底线与 OCT 测量的动态范围和步骤。横断面研究。使用定制和商业软件对青光眼诊所 173 名青光眼受试者的 252 只眼睛和 92 名非青光眼受试者的 123 只眼睛的成像进行量化。来自 OCT（视网膜神经纤维层 [RNFL]、神经节细胞内丛状层 [GCIPL]）和 OCTA（定制：视盘周围血管面积密度 [pVAD]、黄斑血管面积密度 [mVAD]、黄斑血管骨架密度 [mVSD]；商业：视盘周围灌注密度 [pPDZ]、黄斑灌注密度 [mPDZ]、黄斑血管密度 [mVDZ]）的指标为通过线性变化点分析、测量楼层和到达楼层的台阶，根据视野平均偏差 (MD) 进行绘制。青光眼眼的平均MD（dB）为-5.77（-6.45至-5.10）。轻度青光眼（MD>-6）、中度青光眼（MD-6至-12）和重度青光眼（MD<-12）的眼睛数量分别为164眼、50眼和38眼。 pPDZ 产生的最低估计下限为 −26.6 dB（标准误差 [SE] 1.53），其次是 OCTA 黄斑指标（−25 至 −21 dB；SE 1.03）和 pVAD（−17.6 dB，SE 1.06）。 RNFL 和 GCIPL 产生的下限分别为 -17.8 (SE 0.927) 和 -23.6 dB (SE 1.14)。到达测量楼层的步数最多的是 RNFL (7.20) 和 GCIPL (7.33)，其次是 pPDZ (4.25)、mVAD (3.87) 和 mVSD (3.81)，pVAD、mPDZ 和 mVDZ 的步数为 2.5 或更少。 pPDZ、mVAD 和 mVSD 在其动态范围内大约有 4 个步骤，没有真正的测量平台，因此可能有助于评估晚期青光眼进展。提高 OCTA 重测可重复性可以增加 OCTA 指标的步骤数，从而提高其临床实用性。
To compare dynamic ranges and steps to measurement floors of peripapillary and macular metrics from a complex signal-based optical microangiography (OMAGC) optical coherence tomography angiography (OCTA) device for glaucoma with those of OCT measurements. Cross-sectional study. Imaging of 252 eyes from 173 glaucoma subjects and 123 eyes from 92 non-glaucoma subjects from a glaucoma clinic was quantified using custom and commercial software. Metrics from OCT (retinal nerve fiber layer [RNFL], ganglion cell-inner plexiform layer [GCIPL]) and OCTA (custom: peripapillary vessel area density [pVAD], macular vessel area density [mVAD], macular vessel skeleton density [mVSD]; commercial: peripapillary perfusion density [pPDZ], macular perfusion density [mPDZ], macular vessel density [mVDZ]) were plotted against visual field mean deviation (MD) with linear change-point analyses, measurement floors, and steps to floors. Mean MD (dB) for glaucomatous eyes was −5.77 (−6.45 to −5.10). The number of eyes with mild glaucoma (MD >−6), moderate glaucoma (MD −6 to −12), and severe glaucoma (MD <−12) were 164, 50, and 38, respectively. pPDZ yielded the lowest estimated floor at −26.6 dB (standard error [SE] 1.53), followed by OCTA macular metrics (−25 to −21 dB; SE 1.03) and pVAD (−17.6 dB, SE 1.06). RNFL and GCIPL produced floors at −17.8 (SE 0.927) and −23.6 dB (SE 1.14). The highest number of steps to measurement floor belonged to RNFL (7.20) and GCIPL (7.33), followed by pPDZ (4.25), mVAD (3.87), and mVSD (3.81), with 2.5 or fewer steps for pVAD, mPDZ, and mVDZ. pPDZ, mVAD, and mVSD had approximately 4 steps within their dynamic ranges, without true measurement floors, and thus may be useful in evaluating advanced glaucomatous progression. Improving OCTA test-retest repeatability could augment number of steps for OCTA metrics, increasing their clinical utility.
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影响因子：
3.7
作者：
Munk MR;Giannakaki-Zimmermann H;Berger L;Huf W;Ebneter A;Wolf S;Zinkernagel MS
通讯作者：
Zinkernagel MS
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
13.7
作者：
Tham, Yih-Chung;Li, Xiang;Cheng, Ching-Yu
通讯作者：
Cheng, Ching-Yu
影响因子：
--
作者：
Raza, Ali S.;Cho, Jungsuk;de Moraes, Carlos G. V.;Wang, Min;Zhang, Xian;Kardon, Randy H.;Liebmann, Jeffrey M.;Ritch, Robert;Hood, Donald C.
通讯作者：
Hood, Donald C.
影响因子：
3.5
作者：
Chu, Zhongdi;Lin, Jason;Wang, Ruikang K.
通讯作者：
Wang, Ruikang K.