Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19.
Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19.
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DOI：
10.3390/v14030624
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发表时间：
2022-03-17
期刊：
影响因子：
--
通讯作者：
Triki H
中科院分区：
文献类型：
--
作者：
Chouikha A;Fares W;Laamari A;Haddad-Boubaker S;Belaiba Z;Ghedira K;Kammoun Rebai W;Ayouni K;Khedhiri M;Ben Halima S;Krichen H;Touzi H;Ben Dhifallah I;Guerfali FZ;Atri C;Azouz S;Khamessi O;Ardhaoui M;Safer M;Ben Alaya N;Guizani I;Kefi R;Gdoura M;Triki H
记录SARS-CoV-2变种在世界不同区域的传播动态，对于监测病毒在世界范围内的传播和促进全球抗击这一流行病的努力至关重要。突尼斯已经经历了几波新冠肺炎疫情，造成了大量感染和死亡。本研究提供了17个月来在突尼斯流行的SARS-CoV-2不同谱系的遗传信息。通过全基因组测序、S基因部分测序和变异特异性实时RT-PCR检测，对1,359个样本进行了谱系划分。SARS-CoV-2的48个不同谱系被确定，包括令人关注的变种(VOCs)、感兴趣的变种(VOIS)和监测中的变种(VUM)，特别是Alpha、Beta、Delta、A.27、Zeta和Eta。第一波仅限于输入病例和与进口有关的病例，其特点是有少量阳性样本和谱系。在第二波中，发现了大量的谱系；第三波以阿尔法VOC为主，第四波以三角洲VOC为主。这项研究为新冠肺炎的全球背景增加了新的基因组数据，特别是来自北非地区的数据，并强调了及时对流行毒株进行分子表征的重要性。
Documenting the circulation dynamics of SARS-CoV-2 variants in different regions of the world is crucial for monitoring virus transmission worldwide and contributing to global efforts towards combating the pandemic. Tunisia has experienced several waves of COVID-19 with a significant number of infections and deaths. The present study provides genetic information on the different lineages of SARS-CoV-2 that circulated in Tunisia over 17 months. Lineages were assigned for 1359 samples using whole-genome sequencing, partial S gene sequencing and variant-specific real-time RT-PCR tests. Forty-eight different lineages of SARS-CoV-2 were identified, including variants of concern (VOCs), variants of interest (VOIs) and variants under monitoring (VUMs), particularly Alpha, Beta, Delta, A.27, Zeta and Eta. The first wave, limited to imported and import-related cases, was characterized by a small number of positive samples and lineages. During the second wave, a large number of lineages were detected; the third wave was marked by the predominance of the Alpha VOC, and the fourth wave was characterized by the predominance of the Delta VOC. This study adds new genomic data to the global context of COVID-19, particularly from the North African region, and highlights the importance of the timely molecular characterization of circulating strains.
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影响因子：
11.8
作者：
Fourati S;Decousser JW;Khouider S;N'Debi M;Demontant V;Trawinski E;Gourgeon A;Gangloff C;Destras G;Bal A;Josset L;Soulier A;Costa Y;Gricourt G;Lina B;Lepeule R;Pawlotsky JM;Rodriguez C
通讯作者：
Rodriguez C
影响因子：
7.4
作者：
Post L;Marogi E;Moss CB;Murphy RL;Ison MG;Achenbach CJ;Resnick D;Singh L;White J;Boctor MJ;Welch SB;Oehmke JF
通讯作者：
Oehmke JF
影响因子：
3.7
作者：
Bhoyar RC;Jain A;Sehgal P;Divakar MK;Sharma D;Imran M;Jolly B;Ranjan G;Rophina M;Sharma S;Siwach S;Pandhare K;Sahoo S;Sahoo M;Nayak A;Mohanty JN;Das J;Bhandari S;Mathur SK;Kumar A;Sahlot R;Rojarani P;Lakshmi JV;Surekha A;Sekhar PC;Mahajan S;Masih S;Singh P;Kumar V;Jose B;Mahajan V;Gupta V;Gupta R;Arumugam P;Singh A;Nandy A;P V R;Jha RM;Kumari A;Gandotra S;Rao V;Faruq M;Kumar S;Reshma G B;Varma G N;Roy SS;Sengupta A;Chattopadhyay S;Singhal K;Pradhan S;Jha D;Naushin S;Wadhwa S;Tyagi N;Poojary M;Scaria V;Sivasubbu S
通讯作者：
Sivasubbu S
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM