Schizotypal personality disorder: a current review.

Schizotypal personality disorder: a current review.
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DOI:
10.1007/s11920-014-0452-1
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发表时间:
2014-07
影响因子:
6.7
通讯作者:
Siever, Larry J.
Siever, Larry J.
中科院分区:
医学2区
文献类型:
--
作者:
Rosell, Daniel R.;Futterman, Shira E.;McMaster, Antonia;Siever, Larry J.

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典型人格障碍(SPD)的研究在临床上很重要,因为它研究不足,治疗具有挑战性,经常被低估或误诊,并与显著的功能障碍相关。SPD也代表了一种中间型精神分裂症谱系表型,因此,可以提供更好的理解遗传学,发病机制和相关精神病的治疗。在这篇综述中,我们讨论了SPD的流行病学和功能障碍相关的最新研究结果;遗传性和遗传学;工作记忆和认知障碍;社会情感障碍;和神经生物学。此外,我们还研究了与治疗SPD患者相关的挑战以及临床建议。最后,我们讨论了未来的方向和需要进一步探索的领域。
The study of schizotypal personality disorder (SPD) is important clinically, as it is understudied, challenging to treat, often under-recognized or misdiagnosed, and associated with significant functional impairment. SPD also represents an intermediate schizophrenia-spectrum phenotype, and therefore, can provide a better understanding of the genetics, pathogenesis, and treatment of related psychotic illnesses. In this review we discuss recent findings of SPD related to epidemiology and functional impairment; heritability and genetics; working memory and cognitive impairments; social-affective disturbances; and neurobiology. Additionally, we examine the challenges associated with treating patients with SPD, as well as clinical recommendations. Finally, we address future directions and areas in need of further exploration.
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发表时间: 2003-12-01
影响因子: 17.7
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