Mast cell-neural interactions contribute to pain and itch.
Mast cell-neural interactions contribute to pain and itch.
复制标题
DOI：
10.1111/imr.12622
复制
发表时间：
2018-03
影响因子：
8.7
通讯作者：
Harvima IT
中科院分区：
文献类型：
--
作者：
Gupta K;Harvima IT
肥大细胞在变态反应和过敏反应中的作用是公认的，但越来越多的证据支持它们在导致疼痛和瘙痒的神经源性炎症中的作用。肥大细胞通过释放致痛介质和致炎介质，启动与感觉神经纤维上的特定伤害感受器的相互通信，充当“动力室”。因此，神经纤维释放炎性和血管活性神经肽，其又以反馈机制激活肥大细胞，从而促进肥大细胞和伤害感受器激活的恶性循环，导致神经源性炎症和疼痛/瘙痒。肥大细胞分化、活化和与炎症、血管和神经系统的细胞间相互作用的潜在机制受到其微环境的深刻影响，从而在理解其对疼痛和瘙痒的贡献方面赋予了巨大的异质性和复杂性。神经源性炎症是疼痛和瘙痒的核心，但肥大细胞释放的促进这一过程的特定介质可能因其位置、刺激、潜在病理、性别和物种而异。因此，在这篇综述中，我们提出了肥大细胞在病理条件下的贡献，包括精神压力加剧的痛苦瘙痒，并经历了大多数银屑病和特应性皮炎患者和不同的疼痛综合征，由于肥大细胞增多症，镰状细胞病和癌症。
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a “power house” by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus. Mechanisms underlying mast cell differentiation, activation, and inter-cellular interactions with inflammatory, vascular and neural systems are deeply influenced by their microenvironment, imparting enormous heterogeneity and complexity in understanding their contribution to pain and pruritus. Neurogenic inflammation is central to both pain and pruritus, but specific mediators released by mast cells to promote this process may vary depending upon their location, stimuli, underlying pathology, gender and species. Therefore, in this review we present the contribution of mast cells in pathological conditions, including distressing pruritus exacerbated by psychologic stress and experienced by the majority of patients with psoriasis and atopic dermatitis and in different pain syndromes due to mastocytosis, sickle cell disease and cancer.
登录
查看更多内容
影响因子：
5.5
作者：
Baraniuk, James N.
通讯作者：
Baraniuk, James N.
DOI：
10.1016/j.jaci.2016.12.980
发表时间：
2017-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Azimi E;Reddy VB;Pereira PJS;Talbot S;Woolf CJ;Lerner EA
通讯作者：
Lerner EA
影响因子：
20.3
作者：
Ballas, Samir K.;Gupta, Kalpna;Adams-Graves, Patricia
通讯作者：
Adams-Graves, Patricia
影响因子：
3.2
作者：
Brandow AM;Farley RA;Panepinto JA
通讯作者：
Panepinto JA
影响因子：
10.3
作者：
Amatya, B.;El-Nour, H.;Nordlind, K.
通讯作者：
Nordlind, K.