Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation.
Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation.
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DOI：
10.1016/j.mce.2021.111391
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发表时间：
2021-09-15
影响因子：
4.1
通讯作者：
Gordon BS
中科院分区：
文献类型：
--
作者：
Rossetti ML;Dunlap KR;Salazar G;Hickner RC;Kim JS;Chase BP;Miller BF;Gordon BS
肌肉质量对健康很重要。睾丸雄激素产生减少（性腺功能减退）导致肌肉质量损失，肢体肌肉损失尤其使人衰弱。雄激素替代疗法是唯一的治疗方法，但并不适合所有人。先前的工作表明，活性氧和线粒体降解途径的标记物在阉割后的肢体肌肉中更高。因此，我们测试了抗氧化剂是否保留了去势手术的雄性小鼠的肢体肌肉质量。用白藜芦醇（一种通用抗氧化剂）或MitoQ（一种线粒体靶向抗氧化剂）处理去势小鼠亚组。相对非去势对照小鼠，瘦体重、肢体肌肉质量和握力仅在用MitoQ处理的去势小鼠中部分保留。与给药无关，所有去势小鼠的线粒体降解途径标志物均保持升高，与给药无关。因此，线粒体靶向的抗氧化剂可以在性腺功能减退症期间部分保留肢体肌肉质量。
Muscle mass is important for health. Decreased testicular androgen production (hypogonadism) contributes to the loss of muscle mass, with loss of limb muscle being particularly debilitating. Androgen replacement is the only treatment, which may not be feasible for everyone. Prior work showed that markers of reactive oxygen species and markers of mitochondrial degradation pathways were higher in the limb muscle following castration. Therefore, we tested whether an antioxidant preserved limb muscle mass in male mice subjected to a castration surgery. Subsets of castrated mice was treated with resveratrol (a general antioxidant) or MitoQ (a mitochondria targeted antioxidant). Relative non-castrated control mice, lean mass, limb muscle mass, and grip strength were partially preserved only in the castrated mice treated with MitoQ. Independent of treatment, markers of mitochondrial degradation pathways remained elevated in all castrated mice regardless of treatment. Therefore, a mitochondrial targeted antioxidant may partially preserve limb muscle mass during hypogonadism.
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影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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发表时间：
2006-05-01
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影响因子：
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通讯作者：
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