Personality and risk of Alzheimer's disease: new data and meta-analysis.
Personality and risk of Alzheimer's disease: new data and meta-analysis.
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DOI：
10.1016/j.jalz.2013.03.002
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Resnick SM
中科院分区：
文献类型：
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作者：
Terracciano A;Sutin AR;An Y;O'Brien RJ;Ferrucci L;Zonderman AB;Resnick SM
我们在一项长期的纵向研究和对已发表研究的荟萃分析中，检验了广泛的因素和个性的特定方面是否与阿尔茨海默病(AD)发病风险的增加有关。参与者(N=1671)从基线人格评估开始接受长达22年的跟踪调查。Meta分析汇集了多达5项前瞻性研究的结果(N=5054)。神经质得分最高的四分位数(HR=3.1；95%CI=1.6-6.0)或严谨性得分最低的四分位数(HR=3.3；95%CI=1.4-7.4)的个体发生AD的风险增加三倍。在这些特征的组成部分中，自律和抑郁与AD事件的相关性最强。Meta分析证实了神经质(p=2*10−9)和尽职尽责(p=2*10−6)之间的关系，以及对开放性和宜人性的较弱影响(p<；0.05)。目前的研究和荟萃分析表明，人格特征与AD风险的增加有关，其影响大小类似于公认的临床和生活方式风险因素。
We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer’s disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. Participants (N=1671) were followed for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to 5 prospective studies (N=5054). Individuals with scores in the top quartile of neuroticism (HR=3.1; 95%CI=1.6–6.0) or the lowest quartile of conscientiousness (HR=3.3; 95%CI=1.4–7.4) had a three-fold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (p=2*10−9) and conscientiousness (p=2*10−6), along with weaker effects for openness and agreeableness (p<0.05). The current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.
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影响因子：
10.6
作者：
Hek, Karin;Demirkan, Ayse;Lahti, Jari;Terracciano, Antonio;Teumer, Alexander;Cornelis, Marilyn C.;Amin, Najaf;Bakshis, Erin;Baumert, Jens;Ding, Jingzhong;Liu, Yongmei;Marciante, Kristin;Meirelles, Osorio;Nalls, Michael A.;Sun, Yan V.;Vogelzangs, Nicole;Yu, Lei;Bandinelli, Stefania;Benjamin, Emelia J.;Bennett, David A.;Boomsma, Dorret;Cannas, Alessandra;Coker, Laura H.;de Geus, Eco;De Jager, Philip L.;Diez-Roux, Ana V.;Purcell, Shaun;Hu, Frank B.;Rimm, Eric B.;Hunter, David J.;Jensen, Majken K.;Curhan, Gary;Rice, Kenneth;Penman, Alan D.;Rotter, Jerome I.;Sotoodehnia, Nona;Emeny, Rebecca;Eriksson, Johan G.;Evans, Denis A.;Ferrucci, Luigi;Fornage, Myriam;Gudnason, Vilmundur;Hofman, Albert;Illig, Thomas;Kardia, Sharon;Kelly-Hayes, Margaret;Koenen, Karestan;Kraft, Peter;Kuningas, Maris;Massaro, Joseph M.;Melzer, David;Mulas, Antonella;Mulder, Cornelis L.;Murray, Anna;Oostra, Ben A.;Palotie, Aarno;Penninx, Brenda;Petersmann, Astrid;Pilling, Luke C.;Psaty, Bruce;Rawal, Rajesh;Reiman, Eric M.;Schulz, Andrea;Shulman, Joshua M.;Singleton, Andrew B.;Smith, Albert V.;Sutin, Angelina R.;Uitterlinden, Andre G.;Voelzke, Henry;Widen, Elisabeth;Yaffe, Kristine;Zonderman, Alan B.;Cucca, Francesco;Harris, Tamara;Ladwig, Karl-Heinz;Llewellyn, David J.;Raikkonen, Katri;Tanaka, Toshiko;van Duijn, Cornelia M.;Grabe, Hans J.;Launer, Lenore J.;Lunetta, Kathryn L.;Mosley, Thomas H., Jr.;Newman, Anne B.;Tiemeier, Henning;Murabito, Joanne
通讯作者：
Murabito, Joanne
影响因子：
11
作者：
通讯作者：
--
影响因子：
4.8
作者：
Liu, Fei;Liang, Zhihou;Gong, Cheng-Xin
通讯作者：
Gong, Cheng-Xin
影响因子：
9.9
作者：
Kawas, C;Gray, S;Zonderman, A
通讯作者：
Zonderman, A
影响因子：
14
作者：
通讯作者：
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