The Ccr4-Not complex is a key regulator of eukaryotic gene expression.
The Ccr4-Not complex is a key regulator of eukaryotic gene expression.
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DOI：
10.1002/wrna.1332
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发表时间：
2016-07
影响因子：
7.3
通讯作者：
Collart, Martine A.
中科院分区：
文献类型：
--
作者：
Collart, Martine A.
Ccr 4-Not复合物是存在于所有真核生物中的多亚基复合物，其有助于在所有步骤中调节基因表达，从细胞核中信使RNA（mRNA）的产生到其在细胞质中的降解。在细胞核中，它影响必须重塑以进行转录的染色质模板的翻译后修饰，它存在于转录位点并与转录因子以及延伸聚合酶缔合，它与制备新转录物以输出到细胞质的因子相互作用，最后对核质量控制很重要并影响mRNA输出。在细胞质中，它存在于mRNA被翻译的多核糖体中和mRNA被翻译抑制后重定向的RNA颗粒中。它影响mRNA的可翻译性，并且在翻译过程中是必需的，一方面用于共翻译蛋白质相互作用，另一方面用于保持停滞的翻译。它是共同翻译质量控制的相关参与者之一。它还与抑制翻译或在被招募到翻译模板时诱导mRNA脱帽的因子相互作用。最后，Ccr 4-Not携带去腺苷化酶，并且是mRNA衰变的关键参与者，正常翻译终止后的通用mRNA衰变，核糖体持久停滞或携带无义突变的转录物的共翻译mRNA衰变，以及最后由遗传编程变化的外部信号诱导的mRNA衰变。Ccr 4-Not是真核基因表达的主要调节因子。WIREs RNA 2016，7：438-454。doi：10.1002/wrna.1332有关本文的更多资源，请访问WIREs网站。
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for transcription, it is present at sites of transcription and associates with transcription factors as well as with the elongating polymerase, it interacts with the factors that prepare the new transcript for export to the cytoplasm and finally is important for nuclear quality control and influences mRNA export. In the cytoplasm it is present in polysomes where mRNAs are translated and in RNA granules where mRNAs will be redirected upon inhibition of translation. It influences mRNA translatability, and is needed during translation, on one hand for co‐translational protein interactions and on the other hand to preserve translation that stalls. It is one of the relevant players during co‐translational quality control. It also interacts with factors that will repress translation or induce mRNA decapping when recruited to the translating template. Finally, Ccr4‐Not carries deadenylating enzymes and is a key player in mRNA decay, generic mRNA decay that follows normal translation termination, co‐translational mRNA decay of transcripts on which the ribosomes stall durably or which carry a non‐sense mutation and finally mRNA decay that is induced by external signaling for a change in genetic programming. Ccr4‐Not is a master regulator of eukaryotic gene expression. WIREs RNA 2016, 7:438–454. doi: 10.1002/wrna.1332 For further resources related to this article, please visit the WIREs website.
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DOI：
10.1155/2013/548359
发表时间：
2013-01-01
期刊：
ISRN molecular biology
影响因子：
--
作者：
Collart, Martine A
通讯作者：
Collart, Martine A
影响因子：
3.1
作者：
Cui, Yajun;Ramnarain, Deepti B.;Denis, Clyde L.
通讯作者：
Denis, Clyde L.
影响因子：
4.8
作者：
Babbarwal, Vinod;Fu, Jianhua;Reese, Joseph C.
通讯作者：
Reese, Joseph C.
影响因子：
5.6
作者：
Chen, JJ;Rappsilber, J;Denis, CL
通讯作者：
Denis, CL
影响因子：
11.4
作者：
Benson, JD;Benson, M;Struhl, K
通讯作者：
Struhl, K