Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity.
Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity.
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DOI：
10.3390/ijms24065926
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发表时间：
2023-03-21
影响因子：
5.6
通讯作者：
Avenanti, Alessio
中科院分区：
文献类型：
--
作者：
Battaglia, Simone;Di Fazio, Chiara;Vicario, Carmelo M.;Avenanti, Alessio
关键词：
学会识别和应对潜在的威胁对生存至关重要。巴甫洛夫威胁条件反射是研究恐惧学习的神经生物学机制的关键范式。在这篇综述中，我们讨论了特定的神经药理学佐剂在神经化学突触传递中的作用，以及在涉及恐惧记忆的大脑可塑性过程中的作用。我们专注于针对谷氨酸能、去甲肾上腺素能和内源性大麻素系统的新型神经药理学操作，并解决这些神经生物学系统的调节如何影响人类的恐惧消退学习。我们发现n -甲基- d -天冬氨酸（NMDA）激动剂的使用和脂肪酸酰胺水解酶（FAAH）抑制内源性大麻素系统的调节可以通过稳定和调节受体浓度来促进灭绝学习。另一方面，去甲肾上腺素水平的升高动态调节恐惧学习，阻碍长期的消除过程。这些药物干预可以为恐惧和焦虑相关障碍提供新的靶向治疗和预防策略。
Learning to recognize and respond to potential threats is crucial for survival. Pavlovian threat conditioning represents a key paradigm for investigating the neurobiological mechanisms of fear learning. In this review, we address the role of specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well as on brain plasticity processes implicated in fear memory. We focus on novel neuropharmacological manipulations targeting glutamatergic, noradrenergic, and endocannabinoid systems, and address how the modulation of these neurobiological systems affects fear extinction learning in humans. We show that the administration of N-methyl-D-aspartate (NMDA) agonists and modulation of the endocannabinoid system by fatty acid amide hydrolase (FAAH) inhibition can boost extinction learning through the stabilization and regulation of the receptor concentration. On the other hand, elevated noradrenaline levels dynamically modulate fear learning, hindering long-term extinction processes. These pharmacological interventions could provide novel targeted treatments and prevention strategies for fear-based and anxiety-related disorders.
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影响因子：
3
作者：
通讯作者：
--
DOI：
10.1073/pnas.1710819114
发表时间：
2017-08-22
影响因子：
11.1
作者：
Atucha, Erika;Vukojevic, Vanja;Roozendaal, Benno
通讯作者：
Roozendaal, Benno
影响因子：
3
作者：
Barsegyan A;McGaugh JL;Roozendaal B
通讯作者：
Roozendaal B
影响因子：
2.7
作者：
Berlau, Daniel J.;McGaugh, James L.
通讯作者：
McGaugh, James L.
影响因子：
5.3
作者：
Battaglia, Simone;Garofalo, Sara;Starita, Francesca
通讯作者：
Starita, Francesca