Noradrenergic activation of the basolateral amygdala modulates the consolidation of object-in-context recognition memory.
Noradrenergic activation of the basolateral amygdala modulates the consolidation of object-in-context recognition memory.
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DOI：
10.3389/fnbeh.2014.00160
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发表时间：
2014
影响因子：
3
通讯作者：
Roozendaal B
中科院分区：
文献类型：
--
作者：
Barsegyan A;McGaugh JL;Roozendaal B
众所周知，杏仁核基底外侧复合体(BLA)去甲肾上腺素能增强情绪唤醒训练经验的长期记忆的巩固。本研究调查了BLA的这种去甲肾上腺素能激活是否也影响了情境中物体识别记忆的巩固，这是一种评估情景式记忆的低唤醒训练任务。雄性SD大鼠在一个环境中接触两个相同的物体3分钟或10分钟，然后立即暴露在另两个明显不同的环境中。训练结束后，他们立即接受双侧血白内注射去甲肾上腺素(0.3、1.0或3.0μg)或β肾上腺素受体拮抗剂心得安(0.1、0.3或1.0μg)。在24小时的保持测试中，大鼠被放回其中一个训练环境中，两个训练对象各有一个副本。因此，尽管这两个对象都很熟悉，但其中一个对象以前从未在该特定测试上下文中遇到过。因此，如果动物对物体与其背景之间的联系产生了长期记忆，它将花费更多的时间来探索以前在这种背景下没有经历过的物体。生理盐水对照组大鼠在训练3分钟时24小时保持能力较差，在训练10分钟时保持能力较好。在情景客体训练3分钟后给予去甲肾上腺素可引起剂量依赖性的记忆增强，而在训练10分钟后给予普萘洛尔则会导致记忆障碍。这些发现提供了证据，证明训练后去甲肾上腺素能激活BLA也增强了情境中物体识别训练的记忆巩固，使情景类记忆的准确性成为可能。
Noradrenergic activation of the basolateral complex of the amygdala (BLA) is well known to enhance the consolidation of long-term memory of highly emotionally arousing training experiences. The present study investigated whether such noradrenergic activation of the BLA also influences the consolidation of object-in-context recognition memory, a low-arousing training task assessing episodic-like memory. Male Sprague–Dawley rats were exposed to two identical objects in one context for either 3 or 10 min, immediately followed by exposure to two other identical objects in a distinctly different context. Immediately after the training they received bilateral intra-BLA infusions of norepinephrine (0.3, 1.0, or 3.0 μ g) or the β-adrenoceptor antagonist propranolol (0.1, 0.3, or 1.0 μ g). On the 24-h retention test, rats were placed back into one of the training contexts with one copy of each of the two training objects. Thus, although both objects were familiar, one of the objects had not previously been encountered in this particular test context. Hence, if the animal generated a long-term memory for the association between an object and its context, it would spend significantly more time exploring the object that was not previously experienced in this context. Saline-infused control rats exhibited poor 24-h retention when given 3 min of training and good retention when given 10 min of training. Norepinephrine administered after 3 min of object-in-context training induced a dose-dependent memory enhancement, whereas propranolol administered after 10 min of training produced memory impairment. These findings provide evidence that post-training noradrenergic activation of the BLA also enhances the consolidation of memory of object-in-context recognition training, enabling accuracy of episodic-like memories.
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影响因子：
2.7
作者：
Berlau, Daniel J.;McGaugh, James L.
通讯作者：
McGaugh, James L.
影响因子：
2.7
作者：
Dix, SL;Aggleton, JP
通讯作者：
Aggleton, JP
影响因子：
2
作者：
Balderas, Israela;Rodriguez-Ortiz, Carlos J.;Bermudez-Rattoni, Federico
通讯作者：
Bermudez-Rattoni, Federico
影响因子：
5.3
作者：
Eacott, MJ;Norman, G
通讯作者：
Norman, G
DOI：
10.1073/pnas.93.15.8016
发表时间：
1996-07-23
影响因子：
11.1
作者：
Cahill, L;Haier, RJ;McGaugh, JL
通讯作者：
McGaugh, JL