Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding.
Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding.
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DOI：
10.1016/j.mvr.2014.09.007
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发表时间：
2015-01
影响因子：
3.1
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Yousefi, Siavash;Liu, Ting;Wang, Ruikang K.
关键词：
基于光学相干层析成像(OCT)的微血管成像技术能够在体内可视化微循环组织床内的三维功能性血管网络。为了从微血管图像中提供血管直径和形态等定量信息，有必要开发有效的血管分割算法。在这篇论文中，我们提出了一种基于混合黑森/强度的方法来分割和量化支配毛细血管床的血管的形状和直径，这些血管由功能OCT在体内成像。该方法利用多尺度Hessian滤波器分割血管等管状结构，但结合基于强度的分割方法，克服了Hessian滤波器对尺度参数选择的敏感性的局限性。这种复合分割方案利用了海森滤波器的形态特性，同时通过基于强度的分割来校正尺度参数的选择。该算法在伤口愈合模型上进行了测试，并通过公开可用的手动分割数据集对其分割血管的性能进行了量化。我们相信，该方法将在眼科微循环研究和视网膜微循环相关疾病的诊断中发挥重要作用。
Optical coherence tomography (OCT) based microangiography is capable of visualizing 3D functional blood vessel networks within microcirculatory tissue beds in vivo. To provide the quantitative information of vasculature from the microangiograms such as vessel diameter and morphology, it is necessary to develop efficient vessel segmentation algorithms. In this paper, we propose to develop a hybrid Hessian/intensity based method to segment and quantify shape and diameter of the blood vessels innervating capillary beds that are imaged by functional OCT in vivo. The proposed method utilizes the multi-scale Hessian filters to segment tubular structures such as blood vessels, but compounded by the intensity-based segmentation method to mitigate the limitations of Hessian filter's sensitivity to the selection of scale parameters. Such compounding segmentation scheme takes the advantage of morphological nature of Hessian filters while correcting for the scale parameter selection by intensity-based segmentation. The proposed algorithm is tested on a wound healing model and its performance of segmentation vessels is quantified by a publicly available manual segmentation dataset. We believe that this method will play an important role in the quantification of micro-angiograms for microcirculation research in ophthalmology and diagnosing retinal eye diseases involved with microcirculation.
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影响因子：
3.7
作者：
Jung Y;Dziennis S;Zhi Z;Reif R;Zheng Y;Wang RK
通讯作者：
Wang RK
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
3.7
作者：
Sohrab M;Wu K;Fawzi AA
通讯作者：
Fawzi AA
影响因子：
10.6
作者：
Staal, J;Abràmoff, MD;van Ginneken, B
通讯作者：
van Ginneken, B
DOI：
10.1097/iae.0b013e31829477f2
发表时间：
2013-10-01
影响因子：
3.3
作者：
Goldenberg, Dafna;Shahar, Jonathan;Goldstein, Michaella
通讯作者：
Goldstein, Michaella