A pilot study of morphometric analysis of choroidal vasculature in vivo, using en face optical coherence tomography.
A pilot study of morphometric analysis of choroidal vasculature in vivo, using en face optical coherence tomography.
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DOI：
10.1371/journal.pone.0048631
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fawzi AA
中科院分区：
文献类型：
--
作者：
Sohrab M;Wu K;Fawzi AA
目的研究体积谱域光学相干断层扫描（SD-OCT）对活体脉络膜血管进行定量测量的能力。对58例视网膜前膜（ERM）、早期年龄相关性黄斑变性（AMD）或网状假性玻璃疣（RPD）患者的58只眼进行了视网膜色素上皮（RPE）以下不同深度的面状脉络膜扫描，以定量脉络膜血管密度和血管大小。对于每例患者，我们使用黄斑体积扫描（6×6 mm立方体）进行血管定量，而高清晰度（HD）横截面光栅扫描用于定性评估脉络膜亚层的血管分布，并测量脉络膜厚度。在58例患者中，女性较多（66%对34%男性），其中14例（24%）患有ERM，11例（19%）患有早期AMD，33例（57%）患有RPD。与所有ERM中的完整脉络膜毛细血管（100%）相比，RPD中没有一只眼睛和仅5/11（45%）的早期AMD眼睛在横截面或C扫描上具有可见的脉络膜毛细血管（p值<0.001）。当比较来自最浅表C扫描的选择区域时，早期AMD组具有最低的血管密度，而RPD具有最高的血管密度（p值0.04）。所有三组的C扫描定性评价显示，ERM中的脉络膜毛细血管颗粒外观更明显，而RPD眼中的基质和较大血管增加。SD-OCT可用于定性和定量评估体内脉络膜血管。我们的研究结果与以前报道的组织病理学研究相关。在所有RPD和大约一半的早期AMD眼睛中，HD横截面或C扫描上缺乏脉络膜毛细血管，这表明AMD，特别是RPD的早期脉络膜受累。
To study the ability of volumetric spectral domain optical coherence tomography (SD-OCT) to perform quantitative measurement of the choroidal vasculature in vivo. Choroidal vascular density and vessel size were quantified using en face choroidal scans from various depths below the retinal pigment epithelium (RPE) in 58 eyes of 58 patients with either epiretinal membranes (ERM), early age-related macular degeneration (AMD), or reticular pseudo-drusen (RPD). For each patient, we used the macular volume scan (6×6 mm cube) for vessel quantification, while high-definition (HD) cross-section raster scans were used to qualitatively assess vascularity of the choroidal sub-layers, and measure choroidal thickness. Of the 58 patients, more were female (66% versus 34% male), of whom 14 (24%) had ERM, 11 (19%) early AMD, and 33 (57%) RPD. Compared to intact choriocapillaris in all ERM (100%), none of the RPD and only 5/11 (45%) early AMD eyes had visible choriocapillaris on either cross section or C-scans (p-value<0.001). When comparing select regions from the most superficial C-scans, early AMD group had lowest vascular density and RPD had highest (p-value 0.04). Qualitative evaluation of C-scans from all three groups revealed a more granular appearance of the choriocapillaris in ERM versus increased stroma and larger vessels in the RPD eyes. SD-OCT can be used to qualitatively and quantitatively assess choroidal vascularity in vivo. Our findings correlate to previously reported histopathologic studies. Lack of choriocapillaris on HD cross-sections or C-scans in all RPD and about half of early AMD eyes suggests earlier choroidal involvement in AMD and specifically, RPD.
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影响因子：
4.4
作者：
Ikuno, Yasushi;Kawaguchi, Kana;Yasuno, Yoshiaki
通讯作者：
Yasuno, Yoshiaki
影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
Jeffery, G
DOI：
10.1007/s00417-011-1620-1
发表时间：
2011-08-01
影响因子：
2.7
作者：
Koizumi, Hideki;Yamagishi, Tetsuya;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru