Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder.
Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder.
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皮质-边缘-小脑回路中的双向因果连接与首发、未用药躯体化障碍的结构改变相关
DOI：
10.3389/fpsyt.2018.00162
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发表时间：
2018
影响因子：
4.7
通讯作者：
Guo W
中科院分区：
文献类型：
--
作者：
Li R;Liu F;Su Q;Zhang Z;Zhao J;Wang Y;Wu R;Zhao J;Guo W
背景：躯体化障碍(SD)的神经生物学涉及皮质-边缘-小脑环的解剖和功能缺陷。本研究旨在检测静息状态下首发、药物未用药的SD患者大脑皮质-边缘-小脑环路与结构缺陷之间的因果联系。方法：对25例首发、药物未用药的SD患者和28例健康对照进行结构和静息状态功能磁共振成像。采用基于体素的形态计量学和格兰杰因果分析(GCA)对数据进行分析。结果：SD患者右侧小脑CRU I区灰质体积(GMV)减少，左侧扣带回前部(ACC)、右侧额中回(MFG)和左侧角回GMV增加。患者的结构改变部分影响了皮质-边缘-小脑回路的因果连通性。SD患者表现为双向皮质-边缘连接异常和双向皮质-小脑和边缘-小脑连接异常。患者右侧MFG的平均GMV与症状自评量表的躯体化因子分和威斯康星卡片分类测验(WCST)的持续性错误反应分呈负相关。从右侧MFG到右侧梭形回/小脑IV、V区的驾驶连接性增强与艾森克个性问卷外倾量表的得分呈负相关。左侧ACC的平均GMV与WCST错误次数和持续错误反应呈负相关。左侧ACC至右侧中回的因果效应与WCST分类数得分呈负相关。结论：我们的研究结果表明，在首发、药物未用药的SD患者中，结构改变对皮质-边缘-小脑环的部分影响。SD患者的解剖改变或因果效应与临床变量之间存在相关性，具有临床意义。本研究强调了皮质-边缘-小脑环路在SD神经生物学中的重要性。
Background: Anatomical and functional deficits in the cortico-limbic-cerebellar circuit are involved in the neurobiology of somatization disorder (SD). The present study was performed to examine causal connectivity of the cortico-limbic-cerebellar circuit related to structural deficits in first-episode, drug-naive patients with SD at rest. Methods: A total of 25 first-episode, drug-naive patients with SD and 28 healthy controls underwent structural and resting-state functional magnetic resonance imaging. Voxel-based morphometry and Granger causality analysis (GCA) were used to analyze the data. Results: Results showed that patients with SD exhibited decreased gray matter volume (GMV) in the right cerebellum Crus I, and increased GMV in the left anterior cingulate cortex (ACC), right middle frontal gyrus (MFG), and left angular gyrus. Causal connectivity of the cortico-limbic-cerebellar circuit was partly affected by structural alterations in the patients. Patients with SD showed bidirectional cortico-limbic connectivity abnormalities and bidirectional cortico-cerebellar and limbic-cerebellar connectivity abnormalities. The mean GMV of the right MFG was negatively correlated with the scores of the somatization subscale of the symptom checklist-90 and persistent error response of the Wisconsin Card Sorting Test (WCST) in the patients. A negative correlation was observed between increased driving connectivity from the right MFG to the right fusiform gyrus/cerebellum IV, V and the scores of the Eysenck Personality Questionnaire extraversion subscale. The mean GMV of the left ACC was negatively correlated with the WCST number of errors and persistent error response. Negative correlation was found between the causal effect from the left ACC to the right middle temporal gyrus and the scores of WCST number of categories achieved. Conclusions: Our findings show the partial effects of structural alterations on the cortico-limbic-cerebellar circuit in first-episode, drug-naive patients with SD. Correlations are observed between anatomical alterations or causal effects and clinical variables in patients with SD, and bear clinical significance. The present study emphasizes the importance of the cortico-limbic-cerebellar circuit in the neurobiology of SD.
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影响因子：
2.6
作者：
Greve, KW;Stickle, TR;Stanford, MS
通讯作者：
Stanford, MS
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