High prevalence of HIV-1 transmitted drug resistance among therapy-naïve Burmese entering travelers at Dehong ports in Yunnan, China.
High prevalence of HIV-1 transmitted drug resistance among therapy-naïve Burmese entering travelers at Dehong ports in Yunnan, China.
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在中国云南省德宏口岸未接受治疗的缅甸入境旅客中，HIV-1传播的耐药性患病率很高
DOI：
10.1186/s12879-018-3130-9
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发表时间：
2018-05-08
影响因子：
3.7
通讯作者：
Xia X
中科院分区：
文献类型：
--
作者：
Xuan Q;Liang S;Qin W;Yang S;Zhang AM;Zhao T;Su H;Xia Z;Wang B;Xia X
人类免疫缺陷病毒1型（HIV-1）抗逆转录病毒治疗（ART）的总体成功受到耐药性的严重挑战。德宏州不仅首次报告了HIV-1感染，而且还在中国进行了抗病毒治疗的实验性采用。HIV-1在德宏州的传播和流行受到跨境活动的影响。HIV-1耐药的特点，初治缅甸人进入云南的旅行者和他们的推测起源仍然没有澄清。2003年至2012年期间，招募了298名在德宏口岸入境的HIV-1感染的缅甸人。对HIV-1 pol基因部分片段进行扩增和测序，分析其耐药突变（drug-resistance mutations，DRMs）。对gag-pol基因进行系统发育分析，以阐明这些耐药菌株的系统发育和进化特征。结果表明，从缅甸入境的HIV-1感染者中，耐药发生率高达12.8%。耐药突变包括1种PI突变（L33 F）、6种NRTI突变和7种NNRTI突变。gag-pol基因系统发育分析显示，德宏州、云南其他地区、邻近省份（广西）和邻近国家（泰国和缅甸）的耐药菌株之间亲缘关系较近。本研究结果显示，HIV耐药位点正从接受耐药治疗的人群向新感染者扩散，提示在HIV感染高危流动人口中开展耐药监测工作的紧迫性。本文的在线版本（10.1186/s12879-018-3130-9）包含补充材料，可供授权用户使用。
The overall success of Human immunodeficiency virus type 1 (HIV-1) antiretroviral therapy (ART) was heavily challenged upon the occurrence of drug resistance. Dehong Prefecture witnessed not only the first report of HIV-1 infection but also the experimental adoption of antiviral treatment in China. The transmission and epidemic of HIV-1 in Dehong is impacted by cross-border activities. The characteristics of HIV-1 drug resistance among therapy-naïve Burmese entering travelers in Yunnan and their speculated origin are still not clarified. Two hundred ninety-eight HIV-1 infected Burmese entering travelers at Dehong ports were recruited between 2003 and 2012. The partial HIV-1 pol gene fragments were amplified and sequenced for the analysis of drug-resistance mutations (DRMs). Phylogenetic analysis on gag-pol gene was conducted to elucidate phylogenetic and evolutionary characteristics of these drug resistant strains. It was figured out that the occurrence ratio of HIV-1 drug resistance among HIV-1 infected entering travelers from Myanmar was up to 12.8%. The resistant mutations covered several types, including one type of PI mutations (L33F), six types of NRTI mutations and seven types of NNRTI. Close genetic relationship was observed in the phylogenetic analysis on gag-pol gene among the drug resistant strains respectively from Dehong, other Yunnan areas, neighboring provinces (Guangxi) and neighboring countries (Thailand and Myanmar). The findings in this study revealed that HIV drug resistant locus is spreading from the population who is receiving drug-resistance treatment to the new infectors, which indicates the urgency of surveillance work on drug resistance among the migrant population with high risks of HIV infection. The online version of this article (10.1186/s12879-018-3130-9) contains supplementary material, which is available to authorized users.
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