Evaluating the virucidal efficacy of hydrogen peroxide vapour.
Evaluating the virucidal efficacy of hydrogen peroxide vapour.
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DOI：
10.1016/j.jhin.2014.02.003
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Otter JA
中科院分区：
文献类型：
--
作者：
Goyal SM;Chander Y;Yezli S;Otter JA
表面污染与某些病毒的传播有关，表面消毒可以是阻断这些病毒传播的有效措施。评估过氧化氢蒸汽（HPV）的体外功效，这是一种气相消毒方法，用于灭活医疗保健，兽医和公共部门中重要的一些结构独特的病毒。研究的病毒有：猫杯状病毒（FCV，一种诺如病毒替代品）；人1型腺病毒；猪传染性胃肠炎冠状病毒（TGEV，一种严重急性呼吸综合征冠状病毒[SARS-CoV]替代物）；禽流感病毒；猪流感病毒（SwIV）。将病毒在20或40 μL的不锈钢圆盘上干燥，并在0.2 m3的环境室中暴露于Clarus L发生器（Bioquell, Horsham， PA， USA）产生的HPV。对每一种病毒进行三份过氧化氢汽化体积的测试：25,27和33ml。在任何汽化体积的测试中，HPV暴露后都没有发现活病毒。HPV对FCV、腺病毒、TGEV和AIV在最低汽化体积（25 mL）时呈病毒毒性（降低> - 4对数）。对于SwIV，由于对照盘上的病毒滴度较低，25ml汽化体积显示>3.8 log降低，27ml和33ml汽化体积显示>4 log降低。HPV对干燥在表面上的结构不同的病毒具有抗病毒作用，这表明HPV可以被考虑用于病毒污染表面的消毒。
Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents. To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV). The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m3 environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33 mL. No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25 mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes. HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces.
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