Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation.
Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation.
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动脉粥样硬化免疫炎症中 PPAR γ 和 Tregs 的机制见解
DOI：
10.3389/fphar.2021.750078
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发表时间：
2021
影响因子：
5.6
通讯作者：
Nie B
中科院分区：
文献类型：
--
作者：
Gao Z;Xu X;Li Y;Sun K;Yang M;Zhang Q;Wang S;Lin Y;Lou L;Wu A;Liu W;Nie B
动脉粥样硬化（AS）是急性心血管疾病和脑血管疾病的主要病理原因，例如急性心肌梗死和脑凋亡，作为免疫介导的炎症性疾病。 。通过拮抗Wnt/β-catenin途径，在脂质代谢，感染和凋亡中起重要作用，调节胆固醇胆固醇和炎症因子很重要。和迁移VSMC。弹药，从而发挥在本次审查中，我们从AS和免疫介导的感染的角度讨论了它们的病理机制，从而概述了PPARγ和TREG的作用，并在抑制稳定的启动中，探讨了对动物学的创造的效果，我们将重点介绍基础研究和临床试验。具有Treg招募能力的激动剂。
Atherosclerosis (AS) is the main pathological cause of acute cardiovascular and cerebrovascular diseases, such as acute myocardial infarction and cerebral apoplexy. As an immune-mediated inflammatory disease, the pathogenesis of AS involves endothelial cell dysfunction, lipid accumulation, foam cell formation, vascular smooth muscle cell (VSMC) migration, and inflammatory factor infiltration. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) plays an important role in lipid metabolism, inflammation, and apoptosis by antagonizing the Wnt/β-catenin pathway and regulating cholesterol efflux and inflammatory factors. Importantly, PPARγ-dependant fatty acid uptake is critical for metabolic programming. Activated PPARγ can exert an anti-atherosclerotic effect by inhibiting the expression of various inflammatory factors, improving endothelial cell function, and restraining the proliferation and migration of VSMCs. Regulatory T cells (Tregs) are the only subset of T lymphocytes that have a completely negative regulatory effect on the autoimmune response. They play a critical role in suppressing excessive immune responses and inflammatory reactions and widely affect AS-associated foam cell formation, plaque rupture, and other processes. Recent studies have shown that PPARγ activation promotes the recruitment of Tregs to reduce inflammation, thereby exerting its anti-atherosclerotic effect. In this review, we provide an overview of the anti-AS roles of PPARγ and Tregs by discussing their pathological mechanisms from the perspective of AS and immune-mediated inflammation, with a focus on basic research and clinical trials of their efficacies alone or in combination in inhibiting atherosclerotic inflammation. Additionally, we explore new ideas for AS treatment and plaque stabilization and establish a foundation for the development of natural PPARγ agonists with Treg recruitment capability.
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影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
6
作者：
Ait-Oufella H;Lavillegrand JR;Tedgui A
通讯作者：
Tedgui A
影响因子：
6
作者：
Ali AJ;Makings J;Ley K
通讯作者：
Ley K
影响因子：
64.8
作者：
Cipolletta, Daniela;Feuerer, Markus;Li, Amy;Kamei, Nozomu;Lee, Jongsoon;Shoelson, Steven E.;Benoist, Christophe;Mathis, Diane
通讯作者：
Mathis, Diane