Influenza A virus vaccines for swine.
Influenza A virus vaccines for swine.
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DOI：
10.1016/j.vetmic.2016.11.026
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发表时间：
2017-07
影响因子：
3.3
通讯作者：
Lewis NS
中科院分区：
文献类型：
--
作者：
Vincent AL;Perez DR;Rajao D;Anderson TK;Abente EJ;Walia RR;Lewis NS
甲型流感病毒（IAV）感染造成的经济损失是巨大的，是一个全球性问题，是养猪业面临的三大健康挑战之一。目前，H1和H3亚型在全球猪中流行，与N1和N2亚型的不同组合相关;然而，IAV的起源、基因星座和抗原组成在不同大陆差异很大。疫苗接种是减轻IAV疾病影响的一种手段，如果所包含的毒株与猪中当前流行的毒株密切匹配，则疫苗最有效。遗传分析提供了序列水平上病毒景观的全景，因此，可以帮助选择匹配良好的猪IAV疫苗株，但单独是不够的。此外，选择适当的猪IAV疫苗株的主要挑战是同一地区多个病毒谱系的共循环，需要多价或广泛交叉反应的抗原。由于猪中这种复杂的IAV生态，需要新的疫苗接种策略和疫苗平台。血凝素（HA）病毒蛋白是中和抗体的主要靶标，其被广泛认为与保护相关。不被先前引发的抗体识别的病毒变体可使主要引发体液应答的传统疫苗无效，并因此导致需要疫苗株重新配制和重新接种。未来，市场上可能会出现新的疫苗平台，为现有疫苗提供替代选择。尽管如此，需要一种合作的方法来改进用于猪的IAV疫苗株的选择。
Economic losses due to influenza A virus (IAV) infections are substantial and a global problem, ranking among the top three major health challenges in the swine industry. Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, and antigenic makeup of IAV vary greatly on different continents. Vaccination is one means of mitigating the effects of IAV disease, and vaccines are most effective if the strains included closely match the currently circulating strains in pigs. Genetic analyses provide panoramic views of the virus landscape at the sequence level and, thus, can aid in the selection of well-matched swine IAV vaccine strains, but is not sufficient alone. Additionally, a major challenge in selecting appropriate swine IAV vaccine strains is the co-circulation of multiple lineages of viruses in the same region, requiring multivalent or broadly cross-reacting antigens. Due to this complex IAV ecology in swine, new vaccination strategies and vaccine platforms are needed. The hemagglutinin (HA) viral protein is the major target of neutralizing antibodies, which are widely considered to be correlated with protection. Virus variants that are not recognized by previously elicited antibodies can render traditional vaccines that primarily elicit humoral responses ineffective, and therefore result in the need for vaccine strain reformulation and re-vaccination. In the future, new vaccine platforms may be on the market that will provide alternative options to those currently available. Nonetheless, a collaborative approach is needed to improve IAV vaccine strain selection for use in swine.
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母源免疫对新生猪群中甲型流感病毒传播的影响。
影响因子：
5.5
作者：
Allerson, Matt;Deen, John;Detmer, Susan E.;Gramer, Marie R.;Joo, Han Soo;Romagosa, Anna;Torremorell, Montserrat
通讯作者：
Torremorell, Montserrat
影响因子：
5.4
作者：
Abente, Eugenio J.;Santos, Jefferson;Vincent, Amy L.
通讯作者：
Vincent, Amy L.
影响因子：
5.4
作者：
Lewis, N. S.;Daly, J. M.;Smith, D. J.
通讯作者：
Smith, D. J.
影响因子：
5.5
作者：
Kappes, Matthew A.;Sandbulte, Matthew R.;Kehrli, Marcus E., Jr.
通讯作者：
Kehrli, Marcus E., Jr.
影响因子：
7.7
作者：
Lewis NS;Russell CA;Langat P;Anderson TK;Berger K;Bielejec F;Burke DF;Dudas G;Fonville JM;Fouchier RA;Kellam P;Koel BF;Lemey P;Nguyen T;Nuansrichy B;Peiris JM;Saito T;Simon G;Skepner E;Takemae N;ESNIP3 consortium;Webby RJ;Van Reeth K;Brookes SM;Larsen L;Watson SJ;Brown IH;Vincent AL
通讯作者：
Vincent AL