The impact of maternally derived immunity on influenza A virus transmission in neonatal pig populations.
The impact of maternally derived immunity on influenza A virus transmission in neonatal pig populations.
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母源免疫对新生猪群中甲型流感病毒传播的影响。
DOI：
10.1016/j.vaccine.2012.11.023
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发表时间：
2013-01-07
期刊：
影响因子：
5.5
通讯作者：
Torremorell, Montserrat
中科院分区：
文献类型：
--
作者：
Allerson, Matt;Deen, John;Detmer, Susan E.;Gramer, Marie R.;Joo, Han Soo;Romagosa, Anna;Torremorell, Montserrat
美国猪场中甲型流感病毒（IAV）暴露和疫苗接种的共性确保了大多数新生猪对IAV具有一定程度的母体免疫力。母体免疫对新生猪群中IAV传播的影响将影响整个猪群中的病毒流行和感染动态。本研究的主要目的是在实验环境中评估母源性免疫对IAV传播的影响。新生猪吮吸初乳并从三个处理组之一的母猪中获得母体（被动）免疫：a）未接种疫苗的对照组（CTRL）或接种了B）同源（PASSV-HOM）或c）异源（PASSV-HET）灭活实验IAV疫苗。通过与实验感染猪（播种猪）直接接触，用IAV对来自上述组的哨兵新生猪进行攻毒，并通过鼻拭子采样每天监测IAV感染。采用易感-感染-传播（SIR）实验模型，通过广义线性模型获得并估计每个治疗组的传播参数。对照组（30/30）和PASSV-HET组（30/30）的哨兵猪均在与种猪接触后感染了IAV，繁殖比估计值分别为10.4（6.6-15.8）和7.1（4.2-11.3）。相比之下，PASSV-HOM组中1/20的哨兵猪在与播种猪接触后被感染，并且繁殖率估计值显著低于CTRL和PASSV-HET组，为0.8（0.1-3.7）。在本研究的条件下，与本研究中定义的血清阴性新生猪和具有异源母体免疫的猪相比，具有同源母体免疫的新生猪中的IAV传播减少。本研究提供了IAV传播的猪与不同类型的母体免疫力，这可能会描述猪群体中的IAV流行和感染动态的影响母体免疫力的估计。
The commonality of influenza A virus (IAV) exposure and vaccination on swine farms in the United States ensures that the majority of neonatal pigs will have some degree of maternal immunity to IAV. The influence of maternal immunity on IAV transmission in neonatal pig populations will impact virus prevalence and infection dynamics across pig populations. The main objective of this study was to assess the impact of maternally derived immunity on IAV transmission in an experimental setting. Neonatal pigs suckled colostrum and derived maternal (passive) immunity from sows in one of three treatment groups: a) non-vaccinated control (CTRL) or vaccinated with b) homologous (PASSV-HOM) or c) heterologous (PASSV-HET) inactivated experimental IAV vaccines. Sentinel neonatal pigs derived from the groups above were challenged with IAV via direct contact with an experimentally infected pig (seeder pig) and monitored for IAV infection daily via nasal swab sampling. A Susceptible-Infectious-Recovered (SIR) experimental model was used to obtain and estimate transmission parameters in each treatment group via a generalized linear model. All sentinel pigs in the CTRL (30/30) and PASSV-HET (30/30) groups were infected with IAV following contact with the seeder pigs and the reproduction ratio estimates were 10.4 (6.6–15.8) and 7.1 (4.2–11.3), respectively. In contrast, 1/20 sentinel pigs in the PASSV-HOM group was infected following contact with the seeder pigs and the reproduction ratio estimate was significantly lower compared to the CTRL and PASSV-HET groups at 0.8 (0.1–3.7). Under the conditions of this study, IAV transmission was reduced in neonatal pigs with homologous maternal immunity compared to seronegative neonatal pigs and pigs with heterologous maternal immunity as defined in this study. This study provides estimates for IAV transmission in pigs with differing types of maternal immunity which may describe the influence of maternal immunity on IAV prevalence and infection dynamics in pig populations.
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影响因子：
3.3
作者：
Vincent, Amy L.;Lager, Kelly M.;Richt, Juergen A.
通讯作者：
Richt, Juergen A.
影响因子：
2.4
作者：
Beaudoin, A.;Johnson, S.;Gramer, M.
通讯作者：
Gramer, M.
DOI：
10.1016/s0301-6226(02)00182-3
发表时间：
2002-11-28
期刊：
LIVESTOCK PRODUCTION SCIENCE
影响因子：
--
作者：
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通讯作者：
Bland, IM
影响因子：
1.5
作者：
Direksin, K;Joo, H;Goyal, SM
通讯作者：
Goyal, SM
影响因子：
1.5
作者：
Ciacci-Zanella, Janice R.;Vincent, Amy L.;Zimmerman, Jeffrey J.
通讯作者：
Zimmerman, Jeffrey J.