Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis.
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis.
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DOI：
10.1093/nar/gkr1181
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Orengo C
中科院分区：
文献类型：
--
作者：
Lees J;Yeats C;Perkins J;Sillitoe I;Rentzsch R;Dessailly BH;Orengo C
Gene 3D http://gene3d.biochem.ucl.ac.uk是主要序列数据库中序列的蛋白质结构域分配的综合数据库。结构域直接映射从CATH数据库中的结构或预测使用来自CATH超家族的代表性配置文件的障碍。如前所述，Gene 3D集成了许多其他蛋白质家族和功能数据库。这些促进了分子功能、结构和进化的复杂关联。Gene 3D现在包括低于同源超家族水平分配的结构域功能家族（FunFam）水平。还对相互作用数据进行了补充。更重要的是，为了帮助多基因组规模数据集的可视化和解释，我们开发了一个新的，经过改造的网站。搜索已经简化了更复杂的过滤结果，沿着与新的工具，基于Cytoscape网络，可视化蛋白质-蛋白质相互作用网络，基因组之间的结构域组成的差异和个人超家族的分类分布。
Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted using a library of representative profile HMMs derived from CATH superfamilies. As previously described, Gene3D integrates many other protein family and function databases. These facilitate complex associations of molecular function, structure and evolution. Gene3D now includes a domain functional family (FunFam) level below the homologous superfamily level assignments. Additions have also been made to the interaction data. More significantly, to help with the visualization and interpretation of multi-genome scale data sets, we have developed a new, revamped website. Searching has been simplified with more sophisticated filtering of results, along with new tools based on Cytoscape Web, for visualizing protein–protein interaction networks, differences in domain composition between genomes and the taxonomic distribution of individual superfamilies.
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影响因子：
14.9
作者：
Keshava Prasad TS;Goel R;Kandasamy K;Keerthikumar S;Kumar S;Mathivanan S;Telikicherla D;Raju R;Shafreen B;Venugopal A;Balakrishnan L;Marimuthu A;Banerjee S;Somanathan DS;Sebastian A;Rani S;Ray S;Harrys Kishore CJ;Kanth S;Ahmed M;Kashyap MK;Mohmood R;Ramachandra YL;Krishna V;Rahiman BA;Mohan S;Ranganathan P;Ramabadran S;Chaerkady R;Pandey A
通讯作者：
Pandey A
影响因子：
14.9
作者：
Lees J;Yeats C;Redfern O;Clegg A;Orengo C
通讯作者：
Orengo C
影响因子：
14.9
作者：
Gilsdorf, Moritz;Horn, Thomas;Boutros, Michael
通讯作者：
Boutros, Michael
影响因子：
14.9
作者：
Chatr-aryamontri, Andrew;Ceol, Arnaud;Palazzi, Luisa Montecchi;Nardelli, Giuliano;Schneider, Maria Victoria;Castagnoli, Luisa;Cesareni, Gianni
通讯作者：
Cesareni, Gianni
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Klimke W;Maglott DR
通讯作者：
Maglott DR