Metastatic cells will take any help they can get.
Metastatic cells will take any help they can get.
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DOI:
10.1016/j.ccr.2011.11.022
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发表时间:
2011-12-13
期刊:
影响因子:
50.3
通讯作者:
Hynes RO
中科院分区:
文献类型:
--
作者:
Hynes RO
Two recent papers in Cancer Cell illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts yielding paracrine signals enhancing osteolytic metastatic growth.
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