Emotion dysregulation and functional connectivity in children with and without a history of major depressive disorder.
Emotion dysregulation and functional connectivity in children with and without a history of major depressive disorder.
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DOI：
10.3758/s13415-018-0564-x
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Lopez KC;Luby JL;Belden AC;Barch DM
最近，人们对理解早期情绪调节（ER）缺陷可能与后期抑郁症相关的神经机制产生了兴趣。据报道，情绪失调和抑郁中的皮质边缘改变可能是一种可能的联系。我们研究了学龄期情绪失调、青春期前皮质边缘静息状态功能连接（rs-FC）和青春期抑郁症状之间的关系。参与者是来自一项学龄前抑郁症纵向研究的143名儿童，他们完成了儿童悲伤管理量表（csm；测量ER）、儿童抑郁量表（CDI-C；测量抑郁症状）和两次静息状态MRI扫描。研究了四个主要感兴趣区域（roi；双侧背外侧前额叶皮层（dlPFC）和杏仁核）和六个被认为有助于ER的目标roi之间的Rs-FC。研究结果显示，学龄ER并不能预测青春期的抑郁症状，但可以预测青春期前dlPFC-脑岛和dlPFC-腹内侧PFC- rs-FC的增加，以及有抑郁史的儿童dlPFC-背前扣带皮层（dACC） rs-FC的增加。在这些特征中，只有青春期前的dlPFC-dACC rs-FC能预测青春期的抑郁症状。然而，dlPFC-dACC连通性并未介导学龄期ER与青春期抑郁症状之间的关系。尽管内质网与抑郁症状之间没有直接关系，也没有显著的rs-FC中介作用，但内质网预测的rs-FC谱与情绪失调与自上而下控制功能异常相关的假设是一致的。然而，这些关系在多大程度上可能会增加日后患抑郁症的风险，目前尚不清楚。
Recent interest has emerged in understanding the neural mechanisms by which deficits in emotion regulation (ER) early in development may relate to later depression. Cortico-limbic alterations reported in emotion dysregulation and depression may be one possible link. We examined the relationships between emotion dysregulation in school age, corticolimbic resting state functional connectivity (rs-FC) in pre-adolescence, and depressive symptoms in adolescence. Participants were 143 children from a longitudinal preschool onset depression study who completed the Children Sadness Management Scale (CSMS; measuring ER), Child Depression Inventory (CDI-C; measuring depressive symptoms), and two resting state MRI scans. Rs-FC between four primary regions of interest (ROIs; bilateral dorsolateral prefrontal cortex (dlPFC) and amygdala) and six target ROIs thought to contribute to ER were examined. Findings showed that ER in school age did not predict depressive symptoms in adolescence, but did predict pre-adolescent increases in dlPFC-insula and dlPFC-ventromedial PFC rs-FC across diagnosis, as well as, increased dlPFC- dorsal anterior cingulate cortex (dACC) rs-FC in children with a history of depression. Of these profiles, only dlPFC-dACC rs-FC in pre-adolescence predicted depressive symptoms in adolescence. However, dlPFC-dACC connectivity did not mediate the relation between ER in school age and depressive symptoms in adolescence. Despite the absence of a direct relationship between ER and depressive symptoms and no significant rs-FC mediation, the rs-FC profiles predicted by ER are consistent with the hypothesis that emotion dysregulation is associated with abnormalities in top-down control functions. The extent to which these relationships might confer greater risk for later depression, however, remains unclear.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
1.7
作者：
Gaffrey, Michael S.;Luby, Joan L.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
默认模式网络连通性的儿童具有学龄前抑郁史的儿童。
DOI：
10.1111/j.1469-7610.2012.02552.x
发表时间：
2012-09
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Gaffrey MS;Luby JL;Botteron K;Repovš G;Barch DM
通讯作者：
Barch DM
影响因子：
25.8
作者：
Cullen, Kathryn R.;Westlund, Melinda K.;Klimes-Dougan, Bonnie;Mueller, Bryon A.;Houri, Alaa;Eberly, Lynn E.;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.