Default mode network connectivity in children with a history of preschool onset depression.
Default mode network connectivity in children with a history of preschool onset depression.
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默认模式网络连通性的儿童具有学龄前抑郁史的儿童。
DOI：
10.1111/j.1469-7610.2012.02552.x
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Gaffrey MS;Luby JL;Botteron K;Repovš G;Barch DM
非典型默认模式网络（DMN）功能连通性先前在抑郁症成人中有报道。然而，关于这一现象的发展性质的数据相对较少。目前的病例对照研究在一个独特的前瞻性样本中检查了DMN，这些样本是有学龄前抑郁症病史的学龄儿童。使用静息状态功能连通性磁共振成像数据和后扣带（PCC）作为感兴趣的种子区域来评估DMN功能连通性。39名接受药物治疗的naïve学龄儿童（21名有学龄前抑郁症病史，18名健康的同龄人）及其家庭被确定为学龄前儿童，并作为联邦资助的学龄前抑郁症研究的一部分，至少每年进行4次前瞻性评估。在学龄前患有抑郁症的儿童中，PCC与颞中回（MTG）、下顶叶和小脑区域之间的连通性下降。在这些儿童中，还发现PCC与亚属和前扣带皮层以及双侧前MTG区域之间的连通性增加。此外，还发现了PCC的非典型功能连接与情绪调节中断之间存在临床相关的“脑行为”关系。据我们所知，这是第一个在学龄前儿童中检查DMN的研究，这些儿童在临床上经历了显著的抑郁综合征。结果表明，学龄前抑郁症史与非典型DMN连通性有关。然而，需要纵向研究来澄清当前发现的非典型DMN连接是学龄前抑郁症的前兆还是后果。
Atypical Default Mode Network (DMN) functional connectivity has been previously reported in depressed adults. However, there is relatively little data informing the developmental nature of this phenomenon. The current case-control study examined the DMN in a unique prospective sample of school-age children with a previous history of preschool depression. DMN functional connectivity was assessed using resting state functional connectivity magnetic resonance imaging data and the Posterior Cingulate (PCC) as a seed region of interest. Thirty-nine medication naïve school age children (21 with a history of preschool depression and 18 healthy peers) and their families who were ascertained as preschoolers and prospectively assessed over at least 4 annual waves as part of a federally funded study of preschool depression were included. Decreased connectivity between the PCC and regions within the middle temporal gyrus (MTG), inferior parietal lobule, and cerebellum was found in children with known depression during the preschool period. Increased connectivity between the PCC and regions within the subgenual and anterior cingulate cortices and anterior MTG bilaterally was also found in these children. Additionally, a clinically relevant ‘brain-behavior’ relationship between atypical functional connectivity of the PCC and disruptions in emotion regulation was identified. To our knowledge, this is the first study to examine the DMN in children known to have experienced the onset of a clinically significant depressive syndrome during preschool. Results suggest that a history of preschool depression is associated with atypical DMN connectivity. However, longitudinal studies are needed to clarify whether the current findings of atypical DMN connectivity are a precursor or a consequence of preschool depression.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
--
作者：
Luby, Joan L.;Si, Xuemei;Belden, Andy C.;Tandon, Mini;Spitznagel, Ed
通讯作者：
Spitznagel, Ed
影响因子：
1.7
作者：
Gaffrey, Michael S.;Luby, Joan L.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
影响因子：
4.2
作者：
Johnson, Marcia K.;Nolen-Hoeksema, Susan;Levin, Yael
通讯作者：
Levin, Yael