The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment.
The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment.
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DOI：
10.1038/s41398-023-02479-2
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发表时间：
2023-05-31
影响因子：
6.8
通讯作者：
Howes, Oliver D.
中科院分区：
文献类型：
--
作者：
Jauhar, Sameer;McCutcheon, Robert A.;Veronese, Mattia;Borgan, Faith;Nour, Matthew;Rogdaki, Maria;Pepper, Fiona;Stone, James M.;Egerton, Alice;Vamvakas, George;Turkheimer, Federico;McGuire, Philip K.;Howes, Oliver D.
神经调节剂多巴胺和兴奋性神经递质谷氨酸都与精神病的发病机制有关，多巴胺拮抗剂仍然是精神病的主要治疗药物。到目前为止，还没有研究在同一精神病患者群体中同时测量抗精神病药物对这两个指标的影响。采用18F-DOPA正电子发射断层扫描和质子磁共振波谱分别测定首发精神病患者（n = 18）和健康对照（n = 20）在接受自然抗精神病药物治疗至少5周前后纹状体多巴胺合成能力（Kicer）和前扣带谷氨酸水平。使用混合线性模型分析基线和随访测量之间的关系以及这种关系的变化。抗精神病药物治疗后，前扣带谷氨酸浓度（p = 0.75）和纹状体Kicer浓度（p = 0.79）均无显著变化。而全纹状体Kicer与前扣带谷氨酸的变化有统计学意义（p = 0.017）。这反映在基线时患者和对照组两种测量之间的显著差异（t = 2.1, p = 0.04），而在随访时没有出现这种差异（t = 0.06, p = 0.96）。虽然我们没有发现抗精神病治疗对多巴胺合成能力和前扣带谷氨酸的绝对测量有任何影响，但前扣带谷氨酸和纹状体多巴胺合成能力之间的关系确实发生了变化，这表明抗精神病治疗影响了谷氨酸和多巴胺之间的关系。
The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date no study has measured the effect of antipsychotics on both of these indices together, in the same population of people with psychosis. Striatal dopamine synthesis capacity (Kicer) and anterior cingulate glutamate were measured using 18F-DOPA positron emission tomography and proton magnetic resonance spectroscopy respectively, before and after at least 5 weeks’ naturalistic antipsychotic treatment in people with first episode psychosis (n = 18) and matched healthy controls (n = 20). The relationship between both measures at baseline and follow-up, and the change in this relationship was analyzed using a mixed linear model. Neither anterior cingulate glutamate concentrations (p = 0.75) nor striatal Kicer (p = 0.79) showed significant change following antipsychotic treatment. The change in relationship between whole striatal Kicer and anterior cingulate glutamate, however, was statistically significant (p = 0.017). This was reflected in a significant difference in relationship between both measures for patients and controls at baseline (t = 2.1, p = 0.04), that was not present at follow-up (t = 0.06, p = 0.96). Although we did not find any effect of antipsychotic treatment on absolute measures of dopamine synthesis capacity and anterior cingulate glutamate, the relationship between anterior cingluate glutamate and striatal dopamine synthesis capacity did change, suggesting that antipsychotic treatment affects the relationship between glutamate and dopamine.
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抗精神病药物对第一期精神病中突触前多巴胺合成能力的影响：一项正电子发射断层扫描研究。
影响因子：
10.6
作者：
Jauhar S;Veronese M;Nour MM;Rogdaki M;Hathway P;Natesan S;Turkheimer F;Stone J;Egerton A;McGuire P;Kapur S;Howes OD
通讯作者：
Howes OD
影响因子：
17.7
作者：
Kapur, S;Zipursky, R;Houle, S
通讯作者：
Houle, S
影响因子：
4.7
作者：
Covey DP;Mateo Y;Sulzer D;Cheer JF;Lovinger DM
通讯作者：
Lovinger DM
影响因子：
4.7
作者：
Egerton A;Bhachu A;Merritt K;McQueen G;Szulc A;McGuire P
通讯作者：
McGuire P
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon