Meat consumption and the risk of incident distal colon and rectal adenoma.
Meat consumption and the risk of incident distal colon and rectal adenoma.
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DOI：
10.1038/bjc.2011.549
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发表时间：
2012-01-31
影响因子：
8.8
通讯作者：
Cross, A. J.
中科院分区：
文献类型：
--
作者：
Ferrucci, L. M.;Sinha, R.;Huang, W-Y;Berndt, S. I.;Katki, H. A.;Schoen, R. E.;Hayes, R. B.;Cross, A. J.
大多数关于肉类和结直肠腺瘤的研究都是通过单次筛查调查普遍事件，从而限制了我们对肉类和肉类相关暴露在早期结直肠癌发生中的作用的理解。在接受基线和随访乙状结肠镜检查的前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验的筛查组参与者中（n=17 072），我们确定了 1008 名患有远端结直肠腺瘤的个体。我们使用多元逻辑回归计算了肉类和肉类相关成分与远端结直肠腺瘤事件之间关联的比值比 (OR) 和 95% 置信区间 (95% CI)。我们观察到红肉、加工肉、血红素铁和硝酸盐/亚硝酸盐与远端结直肠腺瘤呈正相关。烤肉 (OR=1.56, 95% CI=1.04–2.36)、全熟或非常全熟的肉 (OR=1.59, 95% CI=1.05–2.43)、2-氨基-1-甲基-6-苯基-咪唑并[4,5-b]吡啶 (PhIP) (OR=1.75, 95% CI=1.17–2.64)、苯并[a]芘（OR=1.53，95% CI=1.06–2.20）和总诱变活性（OR=1.57，95% CI=1.03–2.40）与直肠腺瘤呈正相关。总铁（饮食和补充剂）（OR=0.69，95% CI=0.56–0.86）和补充剂中的铁（OR=0.65，95% CI=0.44–0.97）与任何远端结直肠腺瘤呈负相关。我们的研究结果表明，几种与肉类相关的成分可能与直肠早期肿瘤最相关。相比之下，总铁和补充剂中的铁与任何远端结直肠腺瘤呈负相关。
Most studies of meat and colorectal adenoma have investigated prevalent events from a single screening, thus limiting our understanding of the role of meat and meat-related exposures in early colorectal carcinogenesis. Among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who underwent baseline and follow-up sigmoidoscopy (n=17 072), we identified 1008 individuals with incident distal colorectal adenoma. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between meat and meat-related components and incident distal colorectal adenoma using multivariate logistic regression. We observed suggestive positive associations for red meat, processed meat, haeme iron, and nitrate/nitrite with distal colorectal adenoma. Grilled meat (OR=1.56, 95% CI=1.04–2.36), well or very well-done meat (OR=1.59, 95% CI=1.05–2.43), 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) (OR=1.75, 95% CI=1.17–2.64), benzo[a]pyrene (OR=1.53, 95% CI=1.06–2.20), and total mutagenic activity (OR=1.57, 95% CI=1.03–2.40) were positively associated with rectal adenoma. Total iron (diet and supplements) (OR=0.69, 95% CI=0.56–0.86) and iron from supplements (OR=0.65, 95% CI=0.44–0.97) were inversely associated with any distal colorectal adenoma. Our findings indicate that several meat-related components may be most relevant to early neoplasia in the rectum. In contrast, total iron and iron from supplements were inversely associated with any distal colorectal adenoma.
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影响因子：
9.8
作者：
Ferrucci, Leah M.;Sinha, Rashmi;Graubard, Barry I.;Mayne, Susan T.;Ma, Xiaomei;Schatzkin, Arthur;Schoenfeld, Philip S.;Cash, Brooks D.;Flood, Andrew;Cross, Amanda J.
通讯作者：
Cross, Amanda J.
影响因子：
3.3
作者：
Fu, Zhenming;Shrubsole, Martha J.;Zheng, Wei
通讯作者：
Zheng, Wei
影响因子：
10.3
作者：
Chan, AT;Ma, J;Fuchs, CS
通讯作者：
Fuchs, CS
影响因子：
6.4
作者：
DEVERDIER, MG;HAGMAN, U;OVERVIK, E
通讯作者：
OVERVIK, E
影响因子：
6.4
作者：
KNEKT, P;REUNANEN, A;HAKULINEN, T
通讯作者：
HAKULINEN, T