Dietary meat intake in relation to colorectal adenoma in asymptomatic women.
Dietary meat intake in relation to colorectal adenoma in asymptomatic women.
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DOI：
10.1038/ajg.2009.102
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发表时间：
2009-05
影响因子：
9.8
通讯作者：
Cross, Amanda J.
中科院分区：
文献类型：
--
作者：
Ferrucci, Leah M.;Sinha, Rashmi;Graubard, Barry I.;Mayne, Susan T.;Ma, Xiaomei;Schatzkin, Arthur;Schoenfeld, Philip S.;Cash, Brooks D.;Flood, Andrew;Cross, Amanda J.
此前没有研究同时评估无症状结肠镜检查妇女的肉类摄入量、肉类烹饪方法和熟度水平、肉类诱变剂（杂环胺（HCAs）和多环芳烃）、血红素铁和亚硝酸盐与结直肠腺瘤之间的关系。在一项横断面多中心结肠镜筛查研究中，807名符合条件的女性中，158名结直肠腺瘤患者和649名对照组满意地完成了有效的食物频率和肉类问卷调查。利用已建立的肉类诱变剂数据库和新的铁和亚硝酸盐数据库，我们全面研究了肉类中可能参与致癌的成分。使用逻辑回归，我们估计了四分位数内肉类相关变量的比值比（OR）和95%置信区间（CI）。红肉与结直肠腺瘤呈正相关（OR第四对第一四分位数= 2.02;95% CI = 1.06-3.83； P趋势= 0.38）。摄入油锅肉（OR = 1.72; 95% CI = 0.96-3.07； P趋势= 0.01）和HCA: 2-氨基-3,8-二甲基咪唑[4,5-f]喹啉（MeIQx） （OR = 1.90; 95% CI = 1.05-3.42； P趋势= 0.07）也与结直肠腺瘤的风险增加有关。新数据库得出的血红素铁和亚硝酸盐的估计值低于以前的评估方法，尽管两种方法对两种暴露都高度相关。虽然没有统计学意义，但肉中的铁和血红素铁与结直肠腺瘤之间存在正相关。在接受结肠镜检查的无症状妇女中，结直肠腺瘤与大量摄入红肉、煎肉和HCA MeIQx有关。其他与肉类有关的接触需要进一步调查。
No previous study has concurrently assessed the association between meat intake, meat cooking methods and doneness levels, meat mutagens (heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons), heme iron, and nitrite from meat and colorectal adenoma in asymptomatic women undergoing colonoscopy. Of 807 eligible women in a cross-sectional multi-center colonoscopy screening study, 158 prevalent colorectal adenoma cases and 649 controls satisfactorily completed validated food frequency and meat questionnaires. Using an established meat mutagen database and new iron and nitrite databases, we comprehensively investigated components of meat that may be involved in carcinogenesis. Using logistic regression we estimated odds ratios (OR) and 95% confidence intervals (CI) within quartiles of meat-related variables. Red meat was positively associated with colorectal adenoma (OR fourth versus first quartile = 2.02; 95% CI = 1.06–3.83; P trend = 0.38). Intake of pan fried meat (OR = 1.72; 95% CI = 0.96–3.07; P trend = 0.01) and the HCA: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) (OR = 1.90; 95% CI = 1.05–3.42; P trend = 0.07) were also associated with increased risk of colorectal adenoma. The new databases yielded lower estimates of heme iron and nitrite than previous assessment methods, although the two methods were highly correlated for both exposures. Although not statistically significant, there were positive associations between iron and heme iron from meat and colorectal adenoma. In asymptomatic women undergoing colonoscopy, colorectal adenomas were associated with high intake of red meat, pan fried meat, and the HCA MeIQx. Other meat-related exposures require further investigation.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
10.3
作者：
Chan, AT;Ma, J;Fuchs, CS
通讯作者：
Fuchs, CS
影响因子：
4.2
作者：
MARTINEZTORRES, C;LEETS, I;LAYRISSE, M
通讯作者：
LAYRISSE, M
DOI：
10.1111/j.1349-7006.2002.tb01281.x
发表时间：
2002-05-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Ochiai, M;Imai, H;Nakagama, H
通讯作者：
Nakagama, H
影响因子：
6.4
作者：
KNEKT, P;REUNANEN, A;HAKULINEN, T
通讯作者：
HAKULINEN, T