Molecular evidence of SARS-CoV-2 in New York before the first pandemic wave.
Molecular evidence of SARS-CoV-2 in New York before the first pandemic wave.
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DOI：
10.1038/s41467-021-23688-7
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发表时间：
2021-06-08
影响因子：
16.6
通讯作者：
Sordillo EM
中科院分区：
文献类型：
--
作者：
Hernandez MM;Gonzalez-Reiche AS;Alshammary H;Fabre S;Khan Z;van De Guchte A;Obla A;Ellis E;Sullivan MJ;Tan J;Alburquerque B;Soto J;Wang CY;Sridhar SH;Wang YC;Smith M;Sebra R;Paniz-Mondolfi AE;Gitman MR;Nowak MD;Cordon-Cardo C;Luksza M;Krammer F;van Bakel H;Simon V;Sordillo EM
许多报告记录了SARS-CoV-2的传播，但在发现本地病例之前有关其传播的信息有限。这可能导致在对病毒起源和传播进行建模时做出错误的假设。在这里，我们利用样本合并策略，在来自纽约西奈山卫生系统的3,040名患者的去识别的呼吸道病原体阴性鼻咽标本中筛选先前未检测到的SARS-CoV-2。这些患者此前曾在2020年前10周接受过呼吸道症状或流感样疾病的评估。我们从早在2020年1月25日收集的标本中鉴定了SARS-CoV-2 RNA，并从2月底至3月初收集的多个样本池中完成了SARS-CoV-2基因组序列，记录了后来激增之前的增加。我们的研究结果提供了在2020年3月第一例正式记录病例和纽约成为COVID-19震中之前整整一个月的散发性SARS-CoV-2感染的证据。马修·M埃尔南德斯和Ana S. Gonzalez-Reiche及其同事报告了在纽约收集的呼吸道病原体阴性鼻咽标本中SARSCoV-2感染的证据，这些标本可追溯到该州第一例正式记录病例前一个多月。这一发现为纽约病毒的起源提供了新的见解。
Numerous reports document the spread of SARS-CoV-2, but there is limited information on its introduction before the identification of a local case. This may lead to incorrect assumptions when modeling viral origins and transmission. Here, we utilize a sample pooling strategy to screen for previously undetected SARS-CoV-2 in de-identified, respiratory pathogen-negative nasopharyngeal specimens from 3,040 patients across the Mount Sinai Health System in New York. The patients had been previously evaluated for respiratory symptoms or influenza-like illness during the first 10 weeks of 2020. We identify SARS-CoV-2 RNA from specimens collected as early as 25 January 2020, and complete SARS-CoV-2 genome sequences from multiple pools of samples collected between late February and early March, documenting an increase prior to the later surge. Our results provide evidence of sporadic SARS-CoV-2 infections a full month before both the first officially documented case and emergence of New York as a COVID-19 epicenter in March 2020. Matthew M. Hernandez and Ana S. Gonzalez-Reiche and colleagues report evidence of SARSCoV-2 infections in respiratory pathogen-negative nasopharyngeal specimens collected in New York, which date back to over one month before the first officially documented case in the state. The findings provide insights in to the origins of the virus in New York.
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影响因子：
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作者：
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通讯作者：
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