Neural Circuit Motifs in Valence Processing.

Neural Circuit Motifs in Valence Processing.
复制标题

DOI:
10.1016/j.neuron.2018.10.001
复制
发表时间:
2018-10-24
期刊:
影响因子:
16.2
通讯作者:
Tye KM
Tye KM
中科院分区:
医学1区
文献类型:
--
作者:
Tye KM

文献摘要

参考文献

相似文献

我们的大脑如何判断某件事是好是坏?这个计算目标是如何在生物系统中实现的?鉴于价处理对于生存的至关重要性,大脑已经进化出多种策略来在不同层面上解决这个问题。 “情绪效价”的心理学概念现在开始在神经科学中找到基础。这篇综述旨在弥合心理学和神经科学在情绪效价处理方面的差距。在这里,我重点介绍了一组研究,这些研究举例说明了在价处理中作为实现系统反复出现的电路图案。我认为在效价处理中重要的基序包括:1)标记线,2)发散路径,3)相反成分,4)神经调节增益。重要的是,神经底物在价处理中的功能是动态的、上下文相关的,并且由于突触可塑性、竞争机制和稳态需要而在短期和长期范围内发生变化。泰伊重新审视了源自心理学的效价理论概念,以研究神经科学中的效价处理。 Tye 确定了几种用于价处理的神经回路基序,为实现层面上的价处理提供了概念框架。
How do our brains determine whether something is good or bad? How is this computational goal implemented in biological systems? Given the critical importance of valence processing for survival, the brain has evolved multiple strategies to solve this problem at different levels. The psychological concept of “emotional valence” is now beginning to find grounding in neuroscience. This review aims to bridge the gap between psychology and neuroscience on the topic of emotional valence processing. Here, I highlight a subset of studies that exemplify circuit motifs that repeatedly appear as implementational systems in valence processing. The motifs I identify as being important in valence processing include: 1) Labeled lines, 2) Divergent Paths, 3) Opposing Components, and 4) Neuromodulatory Gain. Importantly, the functionality of neural substrates in valence processing is dynamic, context-dependent, and changing across short and long time scales due to synaptic plasticity, competing mechanisms, and homeostatic need. Tye revisits the theoretical concept of valence originating from psychology to the investigation of valence processing in neuroscience. Tye identifies several neural circuit motifs for valence processing to provide a conceptual framework for valence processing on the implementational level.
DOI: 10.1038/nrn2648
发表时间: 2009-06
影响因子: 34.7
作者:
Arnsten, Amy F. T.
通讯作者: Arnsten, Amy F. T.
DOI: 10.1523/jneurosci.0407-15.2015
发表时间: 2015-09-23
影响因子: 5.3
作者:
Amir, Alon;Lee, Seung-Chan;Pare, Denis
通讯作者: Pare, Denis
DOI: 10.1016/j.cell.2014.03.003
发表时间: 2014-03-27
期刊: Cell
影响因子: 64.5
作者:
Anderson DJ;Adolphs R
通讯作者: Adolphs R
DOI: 10.1037/h0045925
发表时间: 1961-01-01
期刊: JOURNAL OF ABNORMAL AND SOCIAL PSYCHOLOGY
影响因子: --
作者:
BANDURA, A;ROSS, SA;ROSS, D
通讯作者: ROSS, D
DOI: 10.1016/j.cell.2018.04.004
发表时间: 2018-05-31
期刊: Cell
影响因子: 64.5
作者:
Allsop SA;Wichmann R;Mills F;Burgos-Robles A;Chang CJ;Felix-Ortiz AC;Vienne A;Beyeler A;Izadmehr EM;Glober G;Cum MI;Stergiadou J;Anandalingam KK;Farris K;Namburi P;Leppla CA;Weddington JC;Nieh EH;Smith AC;Ba D;Brown EN;Tye KM
通讯作者: Tye KM