Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.
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DOI：
10.1016/j.cell.2018.04.004
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发表时间：
2018-05-31
期刊：
影响因子：
64.5
通讯作者：
Tye KM
中科院分区：
文献类型：
--
作者：
Allsop SA;Wichmann R;Mills F;Burgos-Robles A;Chang CJ;Felix-Ortiz AC;Vienne A;Beyeler A;Izadmehr EM;Glober G;Cum MI;Stergiadou J;Anandalingam KK;Farris K;Namburi P;Leppla CA;Weddington JC;Nieh EH;Smith AC;Ba D;Brown EN;Tye KM
观察学习是一种强大的生存工具，允许个体在不直接经历预测线索和惩罚配对的情况下学习威胁预测刺激。这种能力与前扣带皮层（ACC）和基底外侧杏仁核（BLA）有关。为了研究信息是如何通过这个回路进行编码和传输的，我们在小鼠身上进行了电生理记录，观察了一只经历联想恐惧条件反射的示范小鼠，发现BLA投射ACC（ACC→BLA）神经元优先编码社会来源的厌恶性线索信息。抑制ACC→BLA改变了观察条件反射过程中杏仁核对厌恶性线索的实时表征选择性抑制ACC→BLA投射会损害观察性恐惧条件反射的获得，但不会损害其表达。总之，我们表明，来自观察的厌恶值的线索的信息从ACC传输到BLA，这种路由的信息是至关重要的指导观察恐惧条件反射。一个人要观察另一个人的经历并从中学习，信号需要在检测和整合必要的社会线索的过程中从皮层神经元转移到基底外侧杏仁核。
Observational learning is a powerful survival tool, allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning, and found that BLA-projecting ACC (ACC→BLA) neurons preferentially encode socially-derived aversive cue information. Inhibition of ACC→BLA alters real-time amygdala representation of the aversive cue during observational conditioning. Selective inhibition of the ACC→BLA projection impaired acquisition, but not expression, of observational fear conditioning. Together, we show that information derived from observation about the aversive value of the cue is transmitted from the ACC to the BLA and that this routing of information is critically instructive for observational fear conditioning. For one individual to watch another’s experience and learn from it, signals need to move from cortical neurons to the basolateral amygdala during detection and integration of the necessary social cues.
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影响因子：
25
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
通讯作者：
Tye KM
影响因子：
3.7
作者：
Atsak P;Orre M;Bakker P;Cerliani L;Roozendaal B;Gazzola V;Moita M;Keysers C
通讯作者：
Keysers C
影响因子：
3.8
作者：
CASSELL, MD;WRIGHT, DJ
通讯作者：
WRIGHT, DJ
DOI：
10.1098/rstb.2009.0058
发表时间：
2009-08-27
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Bastiaansen JA;Thioux M;Keysers C
通讯作者：
Keysers C
影响因子：
2.7
作者：
Guzman, Yomayra F.;Tronson, Natalie C.;Guedea, Anita;Huh, Kyu Hwan;Gao, Can;Radulovic, Jelena
通讯作者：
Radulovic, Jelena