Inactivation of SARS-CoV-2 isolates from lineages B.1.1.7 (Alpha), P.1 (Gamma) and B.1.110 by heating and UV irradiation.

Inactivation of SARS-CoV-2 isolates from lineages B.1.1.7 (Alpha), P.1 (Gamma) and B.1.110 by heating and UV irradiation.
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通过加热和紫外线照射从谱系B.1.1.7(Alpha),p.1(伽马)和B.1.110的SARS-COV-2分离株失活。

DOI:
10.1016/j.jviromet.2021.114216
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发表时间:
2021-09
影响因子:
3.1
通讯作者:
Fernandez J
Fernandez J
中科院分区:
医学4区
文献类型:
--
作者:
Ulloa S;Bravo C;Ramirez E;Fasce R;Fernandez J

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目前,SARS-CoV-2在全球的快速传播与G进化枝(包括GH、GR、GRY和GV进化枝)有关,这些进化枝与全球98%以上的测序病毒分离株相关。SARS-CoV-2爆发的空前传播速度表明迫切需要采取预防战略。疫苗最近已经上市,抗病毒药物对COVID-19患者的疗效有限。因此,需要知道如何通过不同的物理化学条件降低病毒的感染性,以防止暴露于受污染的材料。本工作描述了加热和照射UV-C光的程序,以减少属于不同的三个谱系的SARS-CoV-2的感染性。物理化学处理的结果显示病毒谱系之间没有差异。确定了有效灭活SARS-CoV-2的分析条件。
Currently, the rapid global spread of SARS-CoV-2 is related to G clade (including GH, GR, GRY and GV clades), which are associated with more than 98 % of sequenced viral isolates worldwide. The unprecedented velocity of spread of SARS-CoV-2 outbreak represents a critical need for prevention strategies. Vaccines are recently being available and antiviral drugs have shown limited efficacy in COVID-19 patients. Thus, it is needed to know how to reduce the infectivity of the virus by different physicochemical conditions in order to prevent exposure to contaminated material. This work describes heating and irradiating UV-C light procedures to reduce the infectivity of SARS-CoV-2 belonging to different three lineages. Results of physicochemical treatment showed no differences among viral lineages. Analytical conditions for efficient inactivation of SARS-CoV-2 were determined.
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