Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging.
Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging.
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DOI：
10.1117/1.3041165
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发表时间：
2008-11
影响因子：
3.5
通讯作者：
Gulsen G
中科院分区：
文献类型：
--
作者：
Unlu MB;Lin Y;Birgul O;Nalcioglu O;Gulsen G
我们提出了同时测量的增强动力学的光学和磁共振（MR）造影剂在小动物乳腺肿瘤模型（R3230 AC）使用组合的MR扩散光学断层扫描（MR-DOT）成像系统。静脉注射小分子量MR造影剂钆-二乙烯三胺-五乙酸（Gd-DTPA）和大分子量光学造影剂吲哚菁绿色（ICG）的混合物进行多模态动态成像。使用琼脂-水基标记物完成光学和MR图像的配准。使用T2和动态T1加权的MR图像，我们将整个肿瘤分为两个感兴趣的区域（ROI）：一个可行的和一个不可行的区域。计算了ROI中的吸收增强。在存活区域观察到ICG的增强。相反，在无活力区有较低的增强。
We present simultaneous measurement of enhancement kinetics of an optical and a magnetic resonance (MR) contrast agent in a small animal breast tumor model (R3230 ac) using a combined MR-diffuse optical tomographic (MR-DOT) imaging system. A mixture of a small molecular-weight MR contrast agent gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA) and a large molecular-weight optical contrast agent indocyanine green (ICG) was administered intravenously for multimodal dynamic imaging. Coregistration of optical and MR images was accomplished using agar-water–based markers. Using T2 and dynamic T1 weighted MR images, we divided the entire tumor into two regions of interest (ROI): a viable and a nonviable region. The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region.
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影响因子：
3.5
作者：
Yuan, BH;Chen, NG;Zhu, Q
通讯作者：
Zhu, Q
影响因子：
3.5
作者：
Unlu, Mehmet Burcin;Birgul, Ozlem;Nalcioglu, Orhan
通讯作者：
Nalcioglu, Orhan
影响因子：
1.9
作者：
Merritt, S;Bevilacqua, F;Nalcioglu, O
通讯作者：
Nalcioglu, O
影响因子：
3.5
作者：
Gulsen, G;Xiong, B;Nalcioglu, O
通讯作者：
Nalcioglu, O
影响因子：
45.3
作者：
Warner, E;Plewes, DB;Narod, SA
通讯作者：
Narod, SA