Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics.
Dissecting the effects of antibiotics on horizontal gene transfer: Analysis suggests a critical role of selection dynamics.
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DOI：
10.1002/bies.201600133
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
You L
中科院分区：
文献类型：
--
作者：
Lopatkin AJ;Sysoeva TA;You L
水平基因转移（HGT）是抗生素耐药性传播的主要机制。相反，通常认为抗生素促进HGT。然而，对文献的仔细分析表明，总体上缺乏支持这一概念的决定性证据。这在很大程度上是由于缺乏明确的定量实验来明确地解决这个问题。在这篇综述中，我们讨论了在何种程度上HGT是负责抗生素耐药性的传播，并检查什么是已知的抗生素对HGT动力学的影响。我们专注于接合，这是负责在全球范围内传播抗生素耐药性的HGT的主要模式。我们的分析表明，需要设计实验来量化HGT，以便于严格的数据解释。此类测量对于开发对抗HGT耐药性传播的新策略至关重要。
Horizontal gene transfer (HGT) is a major mechanism responsible for the spread of antibiotic resistance. Conversely, it is often assumed that antibiotics promote HGT. Careful dissection of the literature, however, suggests a lack of conclusive evidence supporting this notion in general. This is largely due to the lack of well-defined quantitative experiments to address this question in an unambiguous manner. In this review, we discuss the extent to which HGT is responsible for the spread of antibiotic resistance and examine what is known about the effect of antibiotics on the HGT dynamics. We focus on conjugation, which is the dominant mode of HGT responsible for spreading antibiotic resistance on the global scale. Our analysis reveals a need to design experiments to quantify HGT in such a way to facilitate rigorous data interpretation. Such measurements are critical for developing novel strategies to combat resistance spread through HGT.
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