Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study.
Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study.
复制标题
足月出生婴儿早期身体成分指数与神经发育之间的差异关联：巴基斯坦队列的发现：多中心身体成分参考研究。
DOI：
10.1038/s41430-023-01296-6
复制
发表时间：
2023
影响因子：
4.7
通讯作者：
Ariff S
中科院分区：
文献类型：
--
作者：
Ariff S
目的我们检查了来自巴基斯坦卡拉奇的足月出生的低风险婴儿在出生后前 1000 天的去脂量 (FFM) 和脂肪量 (FM) 增加与神经发育之间的关系。设计前瞻性观察性研究，嵌套在更大的多中心身体成分参考研究中。 FFM、FM 和脂肪% 使用测量的氘稀释法估算。 24 个月时根据 INTER-NDA（INTERGROWTH-21st 项目神经发育评估）对神经发育结果进行评估（n= 132）。 结果 患有粗大运动迟缓的儿童在 18 个月时的 FFM 显着较低（8.01±0.97kg 与 7.55±0.20kg）。有积极和消极行为问题的儿童在 24 个月时的脂肪百分比显着较高（20.62±±4.30% vs. 18.23±±5.46%）和 20.89±±4.24% vs. 18.54±±5.38%）。调整协变量后，没有显着的关联。轨迹模型显示，在 12 至 18 个月期间，脂肪堆积每改变一个标准差，负面行为评分就会改变 13.8 分。结论我们的研究结果强调了在为幼儿设计营养干预措施时平衡神经发育和代谢风险的重要性。
ObjectiveWe examined associations between fat free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan.DesignProspective, observational study nested within the larger Multi-Center Body Composition Reference Study. FFM, FM, and fat% were estimated using measured deuterium dilution method. Neurodevelopmental outcomes were assessed at 24 months on the INTER-NDA (INTERGROWTH-21st Project Neurodevelopment Assessment) (n= 132).ResultsChildren with gross motor delays had significantly lower FFM at 18 months (8.01 ± 0.97 kg vs. 7.55 ± 0.20 kg). Children with positive and negative behavior problems had significantly higher fat% at 24 months (20.62 ± 4.30% vs. 18.23 ± 5.46%) and 20.89 ± 4.24% vs. 18.54 ± 5.38%). No associations remained significant after adjusting for covariates. Trajectory modeling showed that between 12 and 18 months, negative behavior scores changed by 13.8 points for every standard deviation change in fat accretion.ConclusionsOur findings highlight the importance of balancing neurodevelopment and metabolic risk when designing nutritional interventions for young children.
登录
查看更多内容
影响因子：
1.9
作者：
Ebenegger, Vincent;Marques-Vidal, Pedro-Manuel;Puder, Jardena J.
通讯作者：
Puder, Jardena J.
DOI：
10.1016/j.jpeds.2013.06.032
发表时间：
2013-12
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Belfort MB;Gillman MW;Buka SL;Casey PH;McCormick MC
通讯作者：
McCormick MC
影响因子：
3.6
作者：
Sobik，Sarah;Sims，Clark R.;Andres，Aline
通讯作者：
Andres，Aline
早产儿的身体成分、工作记忆和气质。
影响因子：
2.1
作者：
Erin E. Morris;Neely C. Miller;J. Haapala;Michael K. Georgieff;S. Ramel
通讯作者：
S. Ramel
影响因子：
3.6
作者：
Butte, NF;Hopkinson, JM;Ellis, KJ
通讯作者：
Ellis, KJ