Quorum quenching agents: resources for antivirulence therapy.
Quorum quenching agents: resources for antivirulence therapy.
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DOI：
10.3390/md12063245
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发表时间：
2014-05-30
期刊：
影响因子：
5.4
通讯作者：
Zhang XH
中科院分区：
文献类型：
--
作者：
Tang K;Zhang XH
抗药性病原体的不断出现是人类健康的一个问题，并突出表明迫切需要开发替代治疗策略。群体感应（QS）调节许多细菌病原体的毒力，因此，是一个有前途的抗病毒治疗的目标，它可能抑制毒力而不是细胞的生长和分裂。这意味着抗性的进化几乎没有选择压力。许多自然群体淬灭剂（QQ）已被确定。此外，已经表明许多微生物能够产生小分子QS抑制剂和/或大分子QQ酶，这可以被视为细菌在竞争环境中获得益处的策略。迄今为止，已经鉴定了30多种海洋QQ细菌，但只有少数进行了深入研究。最近的研究表明，大量的QQ微生物是未被发现的高度多样化的海洋环境中，这些海洋微生物来源的QQ剂可能是宝贵的资源，用于抗毒力治疗。
The continuing emergence of antibiotic-resistant pathogens is a concern to human health and highlights the urgent need for the development of alternative therapeutic strategies. Quorum sensing (QS) regulates virulence in many bacterial pathogens, and thus, is a promising target for antivirulence therapy which may inhibit virulence instead of cell growth and division. This means that there is little selective pressure for the evolution of resistance. Many natural quorum quenching (QQ) agents have been identified. Moreover, it has been shown that many microorganisms are capable of producing small molecular QS inhibitors and/or macromolecular QQ enzymes, which could be regarded as a strategy for bacteria to gain benefits in competitive environments. More than 30 species of marine QQ bacteria have been identified thus far, but only a few of them have been intensively studied. Recent studies indicate that an enormous number of QQ microorganisms are undiscovered in the highly diverse marine environments, and these marine microorganism-derived QQ agents may be valuable resources for antivirulence therapy.
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影响因子：
14.8
作者：
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