Prognostic value of systemic inflammation score in patients with hepatocellular carcinoma after hepatectomy.
Prognostic value of systemic inflammation score in patients with hepatocellular carcinoma after hepatectomy.
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全身炎症评分对肝细胞癌肝切除术后患者的预后价值
DOI：
10.18632/oncotarget.18121
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发表时间：
2017-10-03
期刊：
影响因子：
--
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Shi S;Chen Q;Ye L;Yin D;Li X;Dai Z;He J
炎症在癌症进展中起重要作用。在这项研究中，我们的目的是调查全身炎症生物标志物在肝细胞癌（HCC）患者接受根治性切除术的预后价值。纳入了2008年至2011年期间在中山医院接受根治性切除术的271例HCC患者的数据。Kaplan-Meier生存分析显示γ-谷氨酰转移酶（GGT）和淋巴细胞/单核细胞比值（LMR）与总生存期（OS）和复发时间（TTR）显著相关。我们根据术前血清GGT和LMR建立了全身炎症评分（SIS）。低SIS也与OS和TTR增加显著相关。单因素和多因素分析显示LMR、GGT和SIS是OS和TTR的独立预测因子。根据受试者工作特征曲线下面积评估，SIS对OS的预测能力为0.682（95%CI，0.618-0.746），高于GGT和LMR。总之，低术前LMR和高术前GGT与肝癌患者肝切除术后的不良预后相关。我们的研究结果证实，SIS有资格作为一个新的肝癌患者肝切除术后的预后预测。
Inflammation plays an important role in cancer progression. In this study, we aimed to investigate the prognostic value of the systemic inflammatory biomarkers in hepatocellular carcinoma (HCC) patients undergoing curative resection. Data from 271 HCC patients who underwent curative resection in Zhongshan Hospital between 2008 and 2011 were included. Kaplan-Meier survival analysis showed that gamma-glutamyltransferase (GGT) and lymphocyte-to-monocyte ratio (LMR) were significantly associated with overall survival(OS) and time to recurrence(TTR). We created a systemic inflammation score (SIS) basing on preoperative serum GGT and LMR. Low SIS was also significantly associated with increased OS and TTR. Univariate and multivariate analyses revealed the LMR, GGT and SIS were independent predictors for OS and TTR. The predictive ability of the SIS, as assessed by area under the receiver operating characteristic curve, was 0.682 (95% CI, 0.618-0.746) for OS, which was higher than GGT and LMR. In conclusion, low preoperative LMR and high preoperative GGT were associated with a poor prognosis in HCC patients after hepatectomy. Our results confirmed that the SIS qualifies as a novel prognostic predictor of HCC patients after hepatectomy.
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影响因子：
16.2
作者：
Ford, Earl S.;Schulze, Matthias B.;Boeing, Heiner
通讯作者：
Boeing, Heiner
影响因子：
13.6
作者：
Pintus, F;Mascia, P
通讯作者：
Mascia, P
术前中性粒细胞与淋巴细胞比率升高预示接受肝切除术的肝内胆管癌患者预后不良。
影响因子：
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作者：
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通讯作者：
Dai, Zhi
影响因子：
5.8
作者：
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通讯作者：
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影响因子：
2.6
作者：
Gomez, D.;Farid, S.;Prasad, K. R.
通讯作者：
Prasad, K. R.