Immaturities in reward processing and its influence on inhibitory control in adolescence.
Immaturities in reward processing and its influence on inhibitory control in adolescence.
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DOI：
10.1093/cercor/bhp225
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Luna B
中科院分区：
文献类型：
--
作者：
Geier CF;Terwilliger R;Teslovich T;Velanova K;Luna B
青少年时期不成熟奖励处理的本质以及奖励对认知控制基本要素的影响目前还没有很好的理解。在这里，在功能性磁共振成像，健康的青少年和成人进行了一个修改后的antisaccade任务中，一次又一次的试验奖励的偶然性被操纵。使用一种新的快速，事件相关的设计，使大脑功能的发展差异的奖励处理和反应抑制的时间不同的阶段进行评估。奖励试验与中性试验相比，导致更快的正确的抑制反应，在不同年龄的青少年抑制错误较少。在奖励试验中，血氧水平依赖的信号衰减在腹侧纹状体的青少年在线索评估，然后过度活跃的反应准备过程中，这表明限制在青少年时期的奖励评估和提高反应预期的奖励相比，成年人。重要的是，在青少年中，在奖励试验反应准备过程中也观察到额叶皮层沿着中央前沟的活动增强，这表明奖励调节支持正确的抑制反应的眼控制区域。总的来说，这项工作的特点是特定的不成熟的青少年大脑系统，支持奖励处理，并描述了奖励抑制控制的影响。总之，我们的研究结果表明，可能导致青少年易受不良决策和冒险行为影响的机制。
The nature of immature reward processing and the influence of rewards on basic elements of cognitive control during adolescence are currently not well understood. Here, during functional magnetic resonance imaging, healthy adolescents and adults performed a modified antisaccade task in which trial-by-trial reward contingencies were manipulated. The use of a novel fast, event-related design enabled developmental differences in brain function underlying temporally distinct stages of reward processing and response inhibition to be assessed. Reward trials compared with neutral trials resulted in faster correct inhibitory responses across ages and in fewer inhibitory errors in adolescents. During reward trials, the blood oxygen level–dependent signal was attenuated in the ventral striatum in adolescents during cue assessment, then overactive during response preparation, suggesting limitations during adolescence in reward assessment and heightened reactivity in anticipation of reward compared with adults. Importantly, heightened activity in the frontal cortex along the precentral sulcus was also observed in adolescents during reward-trial response preparation, suggesting reward modulation of oculomotor control regions supporting correct inhibitory responding. Collectively, this work characterizes specific immaturities in adolescent brain systems that support reward processing and describes the influence of reward on inhibitory control. In sum, our findings suggest mechanisms that may underlie adolescents’ vulnerability to poor decision-making and risk-taking behavior.
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