Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA.
Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA.
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DOI：
10.3201/eid2702.203517
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发表时间：
2021-03
影响因子：
11.8
通讯作者：
Kirking HL
中科院分区：
文献类型：
--
作者：
Lewis NM;Duca LM;Marcenac P;Dietrich EA;Gregory CJ;Fields VL;Banks MM;Rispens JR;Hall A;Harcourt JL;Tamin A;Willardson S;Kiphibane T;Christensen K;Dunn AC;Tate JE;Nabity S;Matanock AM;Kirking HL
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的病毒脱落可在症状出现之前发生；对与病毒脱落开始相关的症状进展或传染性知之甚少。我们调查了5个家庭的家庭传播情况，每天连续5天收集样本，从指标患者症状出现后的中位数开始4天开始。2个未采取预防措施的家庭的7名接触者受到感染。在这7例中，有2例在第5天的第3天经逆转录聚合酶链式反应检测为SARS-CoV-2阳性。在第一次阳性检测前1-3天，两人都有轻微的非特异性症状。1名患者从第4天的标本中培养SARS-CoV-2，另1名患者从第4天和第5天的标本中培养SARS-CoV-2。我们还描述了在没有传播的家庭中采取的感染控制措施。接触SARS-CoV-2病毒的人应自我隔离，包括与家庭接触者隔离，戴上口罩，养成手部卫生习惯，并立即进行检测。
Virus shedding in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur before onset of symptoms; less is known about symptom progression or infectiousness associated with initiation of viral shedding. We investigated household transmission in 5 households with daily specimen collection for 5 consecutive days starting a median of 4 days after symptom onset in index patients. Seven contacts across 2 households implementing no precautionary measures were infected. Of these 7, 2 tested positive for SARS-CoV-2 by reverse transcription PCR on day 3 of 5. Both had mild, nonspecific symptoms for 1–3 days preceding the first positive test. SARS-CoV-2 was cultured from the fourth-day specimen in 1 patient and from the fourth- and fifth-day specimens in the other. We also describe infection control measures taken in the households that had no transmission. Persons exposed to SARS-CoV-2 should self-isolate, including from household contacts, wear a mask, practice hand hygiene, and seek testing promptly.
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